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源于内脏脂肪组织的丝氨酸蛋白酶抑制剂研究进展 被引量:1

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摘要 Vaspin (visceral adipose tissue-derived serine protease inhibitor,源于内脏脂肪组织的丝氨酸蛋白酶抑制剂)DNA于2005年日本冈山大学Hidak等首次分离自日本大冢黄褐鼠德岛肥胖大鼠(Otsuka Long-Evans Tokushina Fatty rat,OLETF)的内脏白色脂肪(WAT),这是一肥胖并患有2型糖尿病(T2DM)还具有腹部肥胖、胰岛素抵抗、高血压和血脂异常特征的动物模型。
出处 《中国老年学杂志》 CAS CSCD 北大核心 2012年第14期3113-3118,共6页 Chinese Journal of Gerontology
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  • 1Tan BK, Heutling D, Chen J, Farhatullah S, Adya R, Keay SD, et al. Mefformin decreases the adipokine vaspin in overweight women with polycystic ovary syndrome concomitant with improvement in insulin sensitivity and a decrease in insulin resistance. Diabetes 2008; 57: 1501-1507. 被引量:1
  • 2Gulcelik NE, Karakaya J, Gedik A, Usman A, Gurlek A. Serum vaspin levels in type 2 diabetic women in relation to microvascular complications. Eur J Endocrinol 2009; 160: 65-70. 被引量:1
  • 3Youn BS, Kloting N, Kratzsch J, Lee N, Park JW, Song ES, et al. Serum vaspin concentrations in human obesity and type 2 diabetes. Diabetes 2008; 57: 372-377. 被引量:1
  • 4Kloting N, Berndt J, Kralisch S, Kovacs E Fasshauer M, Schon MR, et al. Vaspin gene expression in human adipose tissue: association with obesity and type 2 diabetes. Biochem Biophys Res Commun 2006; 339: 430-436. 被引量:1
  • 5Gonzalez-Ortiz M, Martinez-Abundis E. Comparison of several formulas to assess insulin action in the fasting state with the hyperglycemic-hyperinsulinemic clamp technique in healthy individuals. Rev Invest Clin 2003; 55:419-422. 被引量:1
  • 6Bao Y, Lu J, Wang C, Yang M, Li H, Zhang X, et al. Optimal waist circumference cutoffs for abdominal obesity in Chinese. Atherosclerosis 2008; 201: 378-384. 被引量:1
  • 7World Health Organization: definition, diagnosis and classification of diabetes mellitus and its complication. WHO/NCD/NCS 1999: 31-33. (Accessed at http://whqlibdoc. who. int/hq/1999/WHO_NCD_NCS_99. 2.pdj-'). 被引量:1
  • 8WHO Expert Consultation. Appropriate body-mass index for Asian populations and its implications for policy and intervention strategies. Lancet 2004; 363: 157-163. 被引量:1
  • 9Seeger J, Ziegelmeier M, Bachmann A, Lossner U, Kratzsch J, Bluher M, et al. Serum levels of the adipokine vaspin in relation to metabolic and renal parameters. J Clin Endocrinol Metab 2008; 93: 247-251. 被引量:1
  • 10Alessi MC, Poggi M, Juhan-Vague I. Plasminogen activator inhibitor-1, adipose tissue and insulin resistance. Curr Opin Lipidol 2007; 18: 240-245. 被引量:1

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