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MicroRNAs在乳腺癌中作用的研究进展 被引量:1

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摘要 MicroRNAs(miRNAs)是一类新发现的非编码RNA分子,通常在转录后水平调控基因表达,广泛参与细胞增殖、分化与凋亡等生命过程。据文献报道,有15种miRNAs位于人类乳腺癌相关断点区域。这表明,特定类型癌症中包括miRNAs在内的基因区域的缺失或获得都与恶性肿瘤的发生有关。miRNAs的表达变化及其对靶基因的综合调控对乳腺癌的发生发展、特殊肿瘤表型的形成及预后等产生深远的影响。
出处 《中华乳腺病杂志(电子版)》 CAS 2012年第3期51-54,共4页 Chinese Journal of Breast Disease(Electronic Edition)
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