摘要
目的:探讨间苯三酚注射液治疗婴幼儿秋季腹泻的临床疗效。方法:80例秋季腹泻患儿随机分为对照组和治疗组各40例。对照组给予常规治疗,治疗组在常规治疗基础上肌肉注射或静脉滴注间苯三酚注射液20 mg/次,2次/d,疗程3～5d。结果:治疗组总有效率77.5%,比对照组47.5%高,差异有统计学意义(P<0.05);治疗组治疗后3 d内大便次数平均每天为(4.6±1.6)次,对照组平均每天为(8.0±2.2)次,两组比较差异有统计学意义(P<0.01);治疗组血Na+、K+、HCO3-浓度均较对照组高,差异有统计学意义(P<0.05);腹泻持续时间治疗组为(118.5±25.7)h,对照组为(122.4±25.6)h,两组比较差异无统计学意义(P>0.05)。结论:间苯三酚注射液治疗小儿秋季腹泻疗效确切,能有效缓解腹泻症状,减轻水、电解质及酸碱平衡紊乱。
Objective： To observe the effect of phloroglucinol injection in clinical treatment of infantile autumn diarrhea. Methods： Eighty infants with autumn diarrhea were randomly divided into two groups, the therapy group （n = 40 ） and the control group （n = 40 ）. The control group was given conventional therapy. On the basis of the conventional therapy, the therapy group was given phloroglucinol injection by muscular injection or intravenous drip, 20 mg, twice a day, 3 - 5 days treatment course. Results ： In the therapy group, the total efficiency was 77.5%, while that in the control group was 47.5%, the difference was statistically significant （ P〈0.05 ）. After treatment for 3 days, stool frequency in the therapy group were （4.6±1.6） times a day, while that in the control group were （8.0±2.2） times a day, the difference was stgtistically significant （P〈0.01）. Blood sodium, potassium, and bicarbonate in the therapy group were higher than those in the control group; the difference was statistically significant （P〈0.05）. Duration of diarrhea in the therapy group were （118.5 ±25.7 ） hours, while that in the control group were （122.4±25.6 ） hours; two groups had no significant difference （P〉0. 05 ）. Conclusions： Phloroglucinol injection in the treatment of infantile autumn diarrhea is curative effect, which can effectively alleviate the symptoms of diarrhea, reduce water, electrolyte and acid-base balance disturbance.
出处
《儿科药学杂志》
CAS
2012年第7期13-16,共4页
Journal of Pediatric Pharmacy
基金
2011湛江市科技攻关项目(编号:2011C3102015)
