摘要
VDR早期和恢复期患儿甲状腺和甲状旁腺分泌功能与正常婴幼儿相比有显著性变化:血T_3和iPTH浓度均明显增高,差异有显著性(P<0.05),而恢复期患儿以血T_4浓度明显增高为显著特点(P<0.05)。婴幼儿在维生素D不缺乏时仍可发生VDR,其发病关键可能在于维生素D活性代谢产物缺乏,特别是1,25(OH)_2D_3的缺乏。另外,T_4/T_3和iPTH/CT分泌比值在对VDR的深入研究中可能有重要临床价值。
Thyroid and parathyroid function were significantly changed in children with vitamin D-deficient rickets (VDR) of the early and the recovery stages in comparison with age-matched controls. Serum triiodothyronine (T3) and immunoreactive parathyroid hormone (iPTH) concentrations were significantly elevated (P<0.05), while in the recovery stage the obvious elevation of thyroxine (T4) became characteristic. That the children may still fall ill despite the administration of vitamin D3 and calcium according to the demand of health protection is possibly due to the deficiency of active vitamin D metabolite, especially 1,25-dihydroxyvitamin D. Under the present conditions of health-keeping measures, the children with VDR may recover autonomously. Probably the T4/T3 and iPTH/GT ratio may be clinically valuable in the studies of VDR.
出处
《中华内分泌代谢杂志》
CAS
CSCD
北大核心
1990年第1期26-28,共3页
Chinese Journal of Endocrinology and Metabolism
关键词
佝偻病
甲状腺
甲状旁腺
分泌功能
Vitamin D-deficient ricket Thyroid and parathyroid function Hormones secretion ratio
