摘要
29例Ⅱ型糖尿病患者,分别接受糖肾平(15例)和D860(14例)双盲治疗4个月。在治疗前、后共作3次馒头餐试验,测定血清胰岛素、C肽和血糖水平,对比观察治疗前后和两组之间胰岛B细胞功能变化,并与正常组(15例)比较。结果表明,治疗前患者胰岛功能明显相对不足,餐后胰岛素分泌延缓,C肽/血糖比值低于正常。治疗后显著改善,空腹C肽/血糖比值正常。糖肾平在4个月疗程中主要通过改善胰岛功能而降血糖。
A 4-month double-blind therapeutic trial was carried out in 29 type II diabetic patients with gliquidone (15 cases) and D860 (14 cases). Steamed bread test was performed in both groups before and at the ends of 2nd and 4th month of the trial to evaluate the changes of patients' B-cell function based on the serum concentrations of insulin, C-peptide and glucose. Compared with 15 healthy volunteers, insulin secretion in both groups of patients was relatively insufficient before treatment: the peak of insulin response to steamed bread stimulation was postponed and the ratio of C-peptide/blood glucose (CP/BG) was significantly reduced. After treatment all these parameters were improved. The CP/BG in fasting state became normal but the peak of insulin secretion was still delayed. As to the degree of the improvement of B-cell function, there was no significant difference between the two groups of patients. We considered that the hypoglyce-mic effect of gliquidone was mainly due to the improvement of patient's B-cell function.
出处
《中华内分泌代谢杂志》
CAS
CSCD
北大核心
1990年第1期17-19,共3页
Chinese Journal of Endocrinology and Metabolism
关键词
糖尿病
胰岛功能
磺脲降血糖药
Type II diabetes B-cell function Sulphonylurea drugs
