摘要
目的探讨γ-氨基丁酸B受体B1亚单位(gamma-aminobutyric acid B receptor 1,GABABR1)基因(G1465A)多态性与汉族脑梗死患者继发癫痫的相关性。方法取脑梗死继发癫痫患者肘静脉血,柱层析法提取血细胞基因组DNA,用PCR-RFLP技术检测GABABR1基因G1465A多态基因型,并与脑梗死无癫痫组和正常对照组进行比较分析。结果 3组GABABR1基因G1465A多态基因型都显示为G/G型,未发现A/G和A/A型。结论汉族人群GABABR1基因(G1465A)未显示多态性,可能不是脑梗死继发癫痫的易感因素。
Objective To investigate the relationship between the polymorphism of GABABR1 （G1465A） gene and epilepsy after cerebral infarction in Hart population. Methods EDTA-blood specimens were collected from test objects. DNA samples were extracted with column chromatography. The polymorphism of GABABR1 （G1465A） gene was detected by PCR-RFLP technique. Then the polymorphism in patients with epilepsy after cerebral infarction was compared with cerebral infarction group without epilepsy and normal control group. Results Only genotype G/G was observed in the three group. We did not find genotype A/G and A/A in our study. Conclusion There may be no association between the poly- morphism of GABABR1 （G1465A） gene and epilepsy after cerebral infarction in Han population.
出处
《中风与神经疾病杂志》
CAS
CSCD
北大核心
2012年第6期527-529,共3页
Journal of Apoplexy and Nervous Diseases
