摘要
目的分析4例肌萎缩侧索硬化（ALS）合并干燥综合征的病例特点。方法通过临床特点、实验室检查、电生理等结果分析ALS合并干燥综合征患者的临床特点及电生理改变。结果4例患者均为中老年女性，进行性病程，3例符合临床拟诊ALS，1例符合实验室支持．临床拟诊ALS。所有患者肌电图显示广泛神经源性损伤。2例患者经免疫调节治疗后运动症状一过性改善。结论对于ALS患者应注意排查伴发干燥综合征的可能，以利于及早对可治性疾病进行治疗。
Objective To describe the clinical characteristics of 4 patients with concomitant amyotrophic lateral sclerosis （ALS） and Sjogren＇ s syndrome. Methods The clinical features, laboratory findings, and eleetrophysiological manifestations etc. of these patients were analyzed. Results Four female patients all developed progressively aggregated weakness in their limb/limbs at the fifth to sixth decades of their lives. According to their neurologie findings, 3 met the criteria of clinical probable ALS, while the other was diagnosed with probable laboratory-supported ALS. All these patients showed diffused patterns of neurogenie changes in eleetromyography tests. Motor symptoms of 2 patients transiently improved after immunomodulation treatments. Conclusion Careful screening of the Sjtigren＇ s syndrome symptoms in patients with ALS is necessary so as to deal with the treatable concomitant disease in time.
出处
《中华神经科杂志》
CAS
CSCD
北大核心
2012年第7期467-470,共4页
Chinese Journal of Neurology
基金
国家自然科学基金重点资助项目（81030019）
北京市自然科学基金资助项目（7102161）
教育部博士点基金资助项目（20100001110084）
首都医学科技发展基金资助项目（SF-2009-Ⅲ-34）
关键词
肌萎缩侧索硬化
干燥综合征
运动神经元病
电生理学
Amyotrophie lateral sclerosis
Sjogren＇ s syndrome
Motor neuron disease
Electrophysiology
