摘要
目的:探讨脾脏窦岸细胞血管瘤的MRI表现和病理学特点。方法:经手术病理证实的脾脏窦岸细胞血管瘤患者5例,回顾性分析其MRI表现及病理学表现。结果:5例中2例为单发,3例为多发,T1WI上病灶呈等、低信号,边界欠清,4例T2WI上病灶呈高信号为主,其内有斑点状低信号,动态增强扫描动脉期病灶呈不均匀中度强化,门脉期呈较均匀的等或稍高信号,病灶内低信号区无强化;1例T2WI上病灶呈低信号,动态增强扫描示病灶无明显强化。病理检查5例,镜下显示脾窦细胞增生,病灶由相互吻合的血管性腔隙组成,腔隙表面覆以呈短柱状或扁平形的内皮细胞,胞质内有含铁血黄素颗粒。免疫组化示内皮细胞和组织细胞标记物阳性。结论:脾脏窦岸细胞血管瘤一般为多发病灶,呈血管瘤样强化及T2WI上病灶内有点状低信号区且其增强后无强化的特点,对本病的诊断具有一定的特异性。
Objective：To study the magnetic resonance imaging （MRI） and pathologic features of splenic littoral cell angioma. Methods： MRI and pathologic features of five patients with surgery and pathology proven littoral cell angioma of the spleen were retrospectively analyzed. Results：Of the 5 patients,there were solitary splenic mass （2 patients） and multi- ple masses （3 patients）. The splenic masses showed iso- or hypo-intensity on T1WI in five patients with indistinct border, and showed predominantly hyper-intensity mixed with tiny spotty hypo-intensity on T2WI in 4 patients. Moderate and heterogeneous enhancement was assessed in arterial phase and relatively homogeneous iso- or slight hyper- intensity in por- tal venous phase without enhancement in the tiny hypo-intensity area. In one patient, the mass showed hypo-intensity on T2 WI and had no enhancement after intravenous contrast administration. Five patients had pathology examination showing the presence of splenic sinus cell proliferation composed of anastomosing vascular channels lined with short columnar or flat endothelial cells with intra-cytoplasmic hemosiderin granules. Positive marker of endothelial cells and histiocytes could be seen on immuno-histochemistry staining. Conclusion：Littoral cell angioma of the spleen most commonly manifests on MRI as multiple hyper-intense masses,the enhanced pattern was similar to that of hemangioma, showing tiny hypointense areas on T2WI yet with no enhancement,which is helpful and with certain specificity in the diagnosis of this disease.
出处
《放射学实践》
2012年第7期761-764,共4页
Radiologic Practice
关键词
脾肿瘤
窦岸细胞血管瘤
磁共振成像
病理学
Splenic neoplasms
Littoral cell angioma
Magnetic resonance imaging
Pathology
