摘要
EB病毒(EB virus,EBV)属于嗜人淋巴细胞双链γ-DNA疱疹病毒,与多种疾病的发生密切相关,但是其确切致病机制尚未明确。弥漫大B细胞淋巴瘤属于非霍奇金淋巴瘤,以往在扁桃体弥漫大B细胞淋巴瘤中EBV的检出率较低,故认为其发生与EBV的相关性较低,最近,由于检测技术的进步,在扁桃体弥漫大B细胞淋巴瘤中EBV的检测有一定的阳性率。本文就EBV感染、EBV感染对宿主细胞的影响、EBV在扁桃体B细胞淋巴瘤发生中的作用及其EBV检测技术的进展方面作一综述。
Epstein-Barr virus （EBV） is a member of the double-strand gamma-DNA herpes virus family, commonly infecting human lymphocytes. Although the virus is closely related to various diseases, the precise pathogenic mechanism is not understood clearly. Diffuse large B cell lymphoma （DLBCL） is a non-Hodgkin’s lymphoma. Formerly the detection rate of EBV in tonsillar DLBCL was low and it was commonly believed that the relationship between EBV and DLBCL is tenuous at most. Recently, with progress in detective technology, a positive association of EBV in tonsillar DLBCL has been more frequently observed. This review summarizes EBV infection and its impact on host cells, the role of EBV in the pathogenesis of tonsillar DLBCL, and progress in detection of EBV.
出处
《国际病理科学与临床杂志》
CAS
2012年第3期236-243,共8页
Journal of International Pathology and Clinical Medicine
关键词
EBV
致瘤机制
扁桃体弥漫大B
细胞淋巴瘤
检测技术
EBV
tumorigenic mechanism
tonsillar diffuse large B cell lymphoma
detection technology
