摘要
目的观察中西医结合治疗方案对慢性肝衰竭患者病死率、并发症发生率以及中医症状改善率的影响。方法采用随机对照设计,将纳入对象随机分配入试验组和对照组,分别给予中西医结合和内科综合治疗。结果经χ2检验,在治疗第8周、第12周、第24周和第48周,2组病死率差异无统计学意义,生存分析表明试验组的生存率略低于对照组,但经Log-rank检验,2组生存曲线差异无统计学意义;治疗第5周、第6周、第7周及第24周4个时间点试验组腹水发生率低于对照组(P<0.05),在治疗第48周试验组的肝性脑病发生率低于对照组(P<0.05);在改善乏力、腹胀、水肿等中医临床症状方面试验组优于对照组。结论个体化复杂干预的中西医结合治疗方案与单纯西医治疗比较,在降低慢性肝衰竭病死率方面未显示出优势,但在控制腹水、肝性脑病等并发症方面有一定作用,特别是在改善中医症状方面具有明显优势。
Objective To observe the effect of combined traditional Chinese medicine （TCM） and western medicine therapy on the mortality rate, the incidence of complications and the improvement in TCM symptoms in patients with chronic liver failure. Methods A randomized controlled study was carried out. The subjects were randomly divided into an experimental group and a control group. The patients in the experimental group underwent the combined TCM and western medicine therapy, and those in the control group underwent conventional internal treatment. Results Log-rank test showed the mortality rates were not significantly different between the two groups at week 8, 12, 24 and 48 （P〉0.05）. The survival analysis showed that the survival rate of the patients in the experimental group was a little lower than that of the control group, however, the difference in the survival curve between the two groups was not significant by testing the homogeneity of survival curves （P〉0.05）. The incidence rate of ascites in experimental group was significantly lower than that in the control group at week 5, 6, 7 and 24 （P〈0.05）, and the incidence rate of hepatic encephalopathy in the experimental group was also significantly lower than that in the control group at week 48 （P〈0.05）. The TCM clinical symptoms such as fatigue malaise, abdominal distension, edema and so on in the experimental group improved more greatly than those in the control group. Conclusions Compared with single western medicine therapy, the individualized, complex and interventional therapeutic regimen of combined TCM and western medicine shows no obvious advantages in reducing the mortality rate of patients with chronic liver failure, but has certain effect on the inhibition of the incidence of ascites, hepatic encephalopathy and other complications, especially it has the obvious advantage in the improvement of TCM symptoms.
出处
《传染病信息》
2012年第3期155-157,共3页
Infectious Disease Information
基金
国家"十一五"科技重大专项(2008ZX10005-007)
军队"十一五"中医药研发推广专项重大临床攻关项目(2006231001)
关键词
中西医结合
肝功能衰竭
治疗结果
integrated traditional Chinese and western medicine therapy
liver failure
therapeutic outcome
