摘要
目的探讨血清胰岛素样生长因子1(IGF-1)、胰岛素敏感指数(ISI)与多囊卵巢综合征(PCOS)的关系。方法采集90例PCOS患者和41例正常对照组血清,应用电化学发光法检测胰岛素水平,葡萄糖氧化酶终点法检测空腹葡萄糖(FPG)水平,酶联免疫吸附试验(ELISA)检测IGF-1水平。结果 1.PCOS患者FPG、血清胰岛素、IGF-1水平明显高于正常对照组(t=16.72,2.24,4.51;P<0.01),且均与患者是否肥胖高度相关(t=5.08,2.07,3.30;P<0.01);2.PCOS患者胰岛素敏感性明显低于对照组,差别有显著性意义(t=3.12,P<0.05);3.PCOS患者血清IGF-1的含量与胰岛素敏感指数呈显著负相关,差别有显著性意义(r=-0.57,P<0.05);对照组血清IGF-1含量与胰岛素敏感指数无明显相关性(r=0.14,P>0.05)。结论多囊卵巢综合征患者存在不同程度的胰岛素抵抗(IR),IGF-1水平增高与PCOS患者发生IR有关,IGF-1可能与PCOS发生、发展有一定的内在联系并起协同作用。
Objective ： To probe into the correlativity of Insulin - like growth factor （ IGF - 1 ） and insulin sensitivity index （ISI） of polycystic ovarian syndrome. Methods： 90 cases of patients with Polycystic ovarian syndrome, PCOS （PCOS group） and 41 cases of normal reproductive age female （control group） were studied in this experiment. The serum levels of insulin like growth factor - 1 were determined by ELISA, The level of Serum insulin was determined by electro - chemoluminescent method, The level of fasting plasma glucose was determined by glucose oxidase method. Results ： 1. The serum levels of FPG, insulin and IGF - 1 in PCOS group were higher than those in the control group （t = 16.72, 2. 24, 4. 51 ; P 〈 0. 01 ）, at the same times, The levels of FPG, insulin and IGF - 1 were correlated highly with obesity （ t = 5.08, 2.07, 3.3 ; P 〈 O. O1 ）. 2. The level of ISI in PCOS group was lower than that in the control group （ t = 3.12, P 〈 0. 05）. 3. The serum levels of IGF - 1 in PCOS group were negatively related to insulin sen- sitivity index significantly （ r = - O. 57 ; P 〈 0. 05 ）. No significant correlation was found amongIGF - 1 and ISI in the control group （ r =0. 14; P 〉0. 05）. Conclusion： Various degrees of insulin resistance accompanies PCOS patient, increasing of the level of IGF - 1 relate to the occurrence of IR. IGF - 1 may have coordinate functions, confirming a possible role of in the development of this disease.
出处
《中国优生与遗传杂志》
2012年第5期90-91,140,共3页
Chinese Journal of Birth Health & Heredity
