摘要
目的观察麻杏石甘汤对哮喘模型小鼠肺功能及氧自由基的影响。方法用鸡卵白蛋白(OVA)抗原液腹腔注射致敏并以低浓度OVA雾化吸入激发制作小鼠哮喘模型,从激发起,麻杏石甘汤、地塞米松片连续7 d灌胃,测定小鼠呼气阻力,并以分光光度法检测小鼠肺组织中超氧化物歧化酶(SOD)及丙二醛(MDA)含量。结果麻杏石甘汤能降低小鼠呼气阻力(Re)。与模型组相比,麻杏石甘汤组小鼠肺组织中SOD活性明显升高而MDA降低(均P<0.05)。结论麻杏石甘汤利于增强肺功能,提高肺组织抗氧化能力。
Objective To observe the effect of MaXingShiGan decoction on lung function, superoxide dismutase（SOD） and malondial- dehyde（MDA） in mouse asthma models. Methods The asthmatic modds were made by ovalbumin （OVA） antigen fluid injected in abdomi- nal cavity and spray inhalation aroused with low density OVA. MaXingShiGan decoction and Dexamethasone tablet were administered for 7 days from stimulating on, observe changes of expiratory resistance （Re）. the concentrations of inflammation factors such as SOD and M DA in the lung tissue of each mouse were detected. Results MaXingShiGan decoction reduced Re, increased SOD and reduceed MDA in the lung tissue compare with the asthmatic group（ P 〈 0. 05 ）. Conclusion MaXingShiGan decoction was advantageous in strengthen lung function and adjusting the balance of oxidants/antioxidants.
出处
《湖北中医药大学学报》
2012年第3期5-7,共3页
Journal of Hubei University of Chinese Medicine
基金
河北省中医药管理局科研项目(编号:2010120)
关键词
支气管哮喘
麻杏石甘汤
肺功能
氧自由基
Asthma
MaXingShiGan
Decoction Lung Function
oxygen free radicals
