摘要
肌切蛋白(scinderin)是一种重要的肌动蛋白结合蛋白,在哺乳动物和脊椎动物中广泛表达.肌切蛋白作为凝溶胶蛋白超家族的成员之一,通过肌动蛋白丝切割、肌动蛋白聚集等方式来控制肌动蛋白的结构.肌切蛋白生物活性具有多样性,除影响肌动蛋白丝重组外,肌切蛋白还参与细胞胞吐作用、调节细胞运动、细胞分化等细胞活动.此外,肌切蛋白在慢性炎症、凝血过程、免疫性疾病和肿瘤发生发展中也发挥了重要作用.本文对肌切蛋白的结构特点、参与调节细胞的功能和机制进行概述.
Scinderin is an actin-binding protein can be found in a wide range of mammals and vertebrate,where its expression varied among different species.As a member of gelsolin superfamily,scinderin affects the organization of actin by severing,nucleating,and assembling in response to Ca2＋,pH and phosphatidylinositol changes.In addition to many found functions of scinderin in the remodeling of actin filament,its roles in cellular processes,including cell exocytosis,motility,differentiation are implied recently.Scinderin also appears to play a pivotal role in chronic inflammation,blood clotting,immunological diseases and tumors.This review will discuss the structure and diversified functions of scinderin in connection with the molecular mechanism involved.
出处
《中国生物化学与分子生物学报》
CAS
CSCD
北大核心
2012年第7期617-623,共7页
Chinese Journal of Biochemistry and Molecular Biology
基金
国家高技术研究发展计划(863计划
No.2012AA02A201)
国家"十二五"计划国家科技重大专项(No.2011ZX09102)
国家自然科学基金(No.81060185
No.30760014)
云南省卫生厅科技内设研究机构项目(No.2011WS0075)资助~~
关键词
肌切蛋白
结构特点
功能
肿瘤
cinderin/adseverin
structural features
functions
tumor
