摘要
目的:评价尼莫地平对弥漫性轴索损伤(DAI)大鼠脑水肿的影响。方法:将200只Wistar大鼠随机分为DAI组和治疗组,建立DAI模型后治疗组给予尼莫地平注射液腹腔注射,剂量为0.5mg/(kg·d),分别于伤前和伤后6h、1d、3d、7d通过检测脑组织含水量反映脑水肿情况,通过观察伊文蓝(EB)含量反映血脑屏障通透性变化。结果:DAI后脑组织含水量和脑组织EB含量峰值分别出现在伤后1d和3d,2组内不同时间点脑组织水含量和脑EB含量差异有统计学意义(均P<0.001),伤后6h和1d、3d时尼莫地平治疗组脑组织水含量明显低于DAI组(P<0.05或P<0.01),伤后6h和1d、3d、7d尼莫地平治疗组脑EB含量明显低于DAI组(均P<0.01)。结论:尼莫地平可以有效控制DAI大鼠的血脑屏障通透性,减轻脑水肿。
Objective： To observe the therapeutic effect of nimodipine on cerebral edema in rats with diffuse axonal injury （DAI）. Methods： Two hundred Wistar rats were divided randomly into two groups, DAI group and treatment group. Nimodipine 0.5 mg/（kg, d） was injected intravenously in treatment group. The brain edema was detected before DAI and 6 h, 1 d, 3 d and 7 d after DAI. The permeability of the blood-brain barrier （BBB） was observed by the change of Evans blue （EB） content. Results：The brain water content was the highest at 1 d after DAI, and the EB content was the highest at 3 d after DAI. There were significant differences in the brain water content and the EB content of different time points between two groups （P 〈 0.001）. The proportion of the brain water content was significantly lower at 6 h, 1 d and 3 d after DAI in treatment group than that of DAI group（P 〈 0.05 or P 〈 0.01）, The EB content was significantly lower at 6 h, 1 d, 3 d and 7 d after DAI in treatment group than that of DAI group（P 〈 0.01）. Conclusion： Nimodipine can decrease the permeability of BBB and alleviate brain edema after DAI.
出处
《天津医药》
CAS
北大核心
2012年第7期704-706,共3页
Tianjin Medical Journal
