摘要
目的描述和探讨江苏省启东市50年肝癌死亡率的特征及其变化趋势。方法采用死亡回顾调查方法获得启东市1958-1971年肝癌死亡率资料，采用肿瘤登记方法获得启东市1972—2007年肝癌死亡率资料。分析肝癌的粗死亡率、中国人口标化率（中标率）和世界人口标化率（世标率）；用变化百分比（PC）和年度变化百分比（APC）来评价率的增长趋势，分析性别和年龄别死亡率、35—64岁截缩率、0～74岁累积死亡率、累积死亡风险和年龄．出生队列死亡率。结果1958--2007年启东市人群自然死亡率经历了由8．62％o降至5．37‰再升至7．75‰的过程，恶性肿瘤死亡率由56．69／10万持续上升至234．97／10万，肝癌死亡率由20．45／10万上升至1972年的49．04／10万，再升至2007年的69．29／10万。根据肿瘤登记资料，1972--2007年期间启东市肝癌死亡占所有恶性肿瘤的34．88％，粗死亡率为58．86／10万，中标率为38．36／10万，世标率为49．37／10万。35～64岁的截缩率为117．08／10万，0～74岁的累积死亡率和累积死亡风险分别为5．15％和5．02％。启东男、女性肝癌粗死亡率分别为90．52／10万和27．93／10万，死亡率性别比为3．24：1。1972--2007年期间，粗死亡率的PC为49．71％，APC为1．41％，呈增长的趋势，但中标率和世标率的APC分别为一1．11％和一0．84％，呈下降的趋势。各时期肝癌的年龄别死亡率显示，40-岁组及以下各年龄组死亡率呈明显的下降趋势。年龄一出生队列分析结果显示，35-岁组及以下各年龄组，即20世纪50年代以后出生的队列人群的肝癌死亡率均呈下降趋势。结论肝癌是江苏省启东市最主要的恶性肿瘤，肝癌粗死亡率持续保持在较高的水平，但标化率已呈现下降趋势；青年人群中的肝癌死亡率也出现了下降趋势。启东市的肝癌防控工作初见成效。
Objective To describe and analyze the charecteristies and trends of liver cancer mortality during the past fifty years in Qidong, China. Methods Retrospective mortality survey was conducted to get the data on liver cancer death in the period of 1958-1971, and the data from 1972 to 2007 were obtained from the records of cancer registration in Qidong. The crude mortality rate （CR） of liver cancer, and age-standardized rate by Chinese population （CASR） and by world population （WASR） were calculated and analyzed. The total percent changes （PC） and annual percent changes （APC） were used for evaluating the increasing trends of the mortality. The sex-specific rate, age-specific rate, truncated rate of the age group 35-64, cumulative rate of the age group 0-74, cumulative risk, period-rate, and the rate for age-birth cohort were compared. Results The natural death rate in Qidong residents for the past five-decade period experienced a wave interval of 8.62‰ in 1958 down to 5.37‰in 1979, and up to 7.75‰ in 2007. Tile mortality rate for all-site cancers was increased from 56.69 per 100,000 to 234.97 per 100,000. The mortality rate of liver cancer, being 20.45 per 100,100 in 1958 was increased to 49.04 per 100,000 in 1972, and up to 69.29 per 100,000 in 2007. According to the registration data of 1972-2007, the death from liver cancer was accounted for 34.88% of all deaths due to cancers, with a CR of 58.86 per 100,000, CASR of 38.36 per 100,000, and WASR, 49.37 Per 100,000 in Qidong. The truncated rate for the age group 35-64 was 117.08 per 100,000, and the cumulative rate for the age group 0-74 and the cumulative risk were 5.15% and 5.02%, respectively. The CRs for males was 90.52 per I00,000 and for females was 27.93 per 100,000, with a sex ratio of 3.24：1. For the period of 1972-2007, the PC for CR was 49.71% , and APC was ＋ 1.41%, showing an increasing variation tendency. The APCs for CASR and WASR, however, were decreasing, with a percentage of - I. 11%, and -0.84%, respectively. The age-s
出处
《中华肿瘤杂志》
CAS
CSCD
北大核心
2012年第7期532-537,共6页
Chinese Journal of Oncology
关键词
肝肿瘤
死亡率
登记
趋势分析
Liver neoplasms
Mortality
Registries
Trend analysis
