摘要
目的:探讨血清肿瘤标志物CEA、CA153和CA125单项和联合检测对肺癌的诊断价值。方法:采用化学发光方法分别检测75例肺癌患者、60例良性肺部疾病患者和70例健康对照者血清中CEA、CA153和CA125水平,并分析上述3项指标在肺癌诊断中的敏感度和特异性。结果:肺癌患者3项肿瘤标志物血清水平均高于良性肺部疾病患者和健康对照者,差异具有统计学意义(P<0.01)。3项标志物的联合检测诊断肺癌的敏感度高于单项标志物检测,其敏感度高达88%,特异性为76.2%。结论:3项肿瘤标志物联合检测可提高诊断肺癌的敏感度。
Objective： To investigate the diagnostic value of combined detection of CEA, CA153 and CA125 in lung cancer. Methods：Chemiluminescence immunoassay was used to measure the serum levels of CEA, CA153 and CA125 in 75 patients with lung cancer, 60 cases with benign pulmonary diseases and 70 health adults. The sensitivi- ties and specificities of 3 markers for the diagnosis of lung cancer were compared. Results ： The levels of serum mark- ers in lung cancer patients were significantly higher than that in patients with benign pulmonary disease and controls. The sensitivity of combined detection was significantly higher than that of single detection, with a sensitivity of 88% , a specificity of 76.2%. Conclusion： The combination of the markers can improve the sensitivity of diagnosis in lung cancer.
出处
《现代肿瘤医学》
CAS
2012年第7期1376-1378,共3页
Journal of Modern Oncology
