摘要
目的探讨帕瑞昔布复合地佐辛用于下肢骨折急性疼痛的临床效果。方法 ASA I^II下肢骨折患者50例,随机分为两组,帕瑞昔布+地佐辛(PD)组和咪达唑伦(M)组,观察记录入室时(T1)、用药后10min后(T2)、体位变动时(T3)的MAP、HR、SpO2,并在各时点进行疼痛视觉模拟评分法(VAS)评估患者疼痛程度。结果在T2、T3时间点中M组MAP、HR、VAS评分较PD组明显升高(P<0.05);在T1时间点两组间MAP、HR、VAS差异无统计学意义(P>0.05);各时间点两组间SpO2差异无统计学意义(P>0.05)。结论帕瑞昔布复合地佐辛能有效减轻下肢骨折患者引起的急性疼痛,而且临床安全性高。
Objective To investigate the clinical effect of parecoxib composite decocine on acute pain during fracture of lower limb. Methods 50 ASA Ⅰ-Ⅱ patients undergoing fracture fixation operation of lower limb with combined spinal-epidural anesthesia were randomly divided into 2 groups： parecoxib composite deeocine group （PD） and midazolam group （M） . MAP, HR, SpO2 of all patients were observed at entering operating room （TI） , at 10minutes after dosage （T2） , at posture changing （T3） , and Visual Analogue Scale （VAS） were performed to all patients at above set point. Results MAP, HR, VAS showed significant difference between M group and PD group, M group was higher than PD group at T2, T3 （P〈0.05） . MAP, HR, VAS had no difference between M group and PD group at T1 （P〉0.05） . SpO2 was no difference between M group and PD group at all set piont （P〉0.05） . Conclusion Parecoxib composite decocine may relieved acute pain from fracture of lower limb, and the clinical safty is high.
出处
《中国医药指南》
2012年第16期227-228,共2页
Guide of China Medicine
关键词
帕瑞昔布
地佐辛
急性疼痛
下肢骨折
疗效
Parecoxib
Decocine
Acute pain
Fracture of lower limb
Clinical effect
