摘要
目的通过分析脑卒中患者的血脂水平，并比较其调脂治疗的临床疗效，探讨血脂对脑卒中发生及预后的影响。方法纳入缺血性脑卒中患者90例、脑出血患者90例，并选择同期在我院住院的非脑卒中患者120例为对照组，应用日立7060全自动生化仪检测甘油三酯（TG）、总胆固醇（Tc）、高密度脂蛋白（HDL-C）和低密度脂蛋白（LDL-C）水平。将脑出血及脑梗死患者随机随机分为调脂治疗组及非调脂治疗组，治疗前、后按照Fugl-Meyer运动功能评分（FMA）、美国国立卫生研究院卒中量表（NIHSS）和日常生活能力（ADL）分级评定疗效。结果脑卒中（出血和梗死）患者的TG、TC、LDL-C水平明显高于对照组，而HDL-C低于对照组，脑出血组TC、LDL-C低于脑梗死组。2个月后，调脂治疗组FAM评分、NIHSS评分和ADL分级评定优于非调脂治疗组。结论高TG、TC、LDL-C及低HDL-C水平是脑卒中的危险因素，适当调脂治疗能改善脑卒中患者的预后。
Objective To explore the impacts of blood lipid on the occurrence and prognosis of stroke by analyzing lipid levels in patients with different types of stroke and comparing the clinical efficacy of lipid-regulating therapy. Methods Levels of triglyceride （ TG ）, total cholesterol （ TC ）, high-density lipoprotein cholesterol （ HDL-C ）, and low-density lipoprotein cholesterol （ LDL-C ）were measured by a Hitachi 7060 automatic biochemical analyzer in 90 patients with cerebral infarction, 90 patients with cerebral hemorrhage, and 120 control subjects without stroke. The stroke patients were randomly assigned to receive lipid-regulating therapy （ lipid-regnlating group ）, or no lipid-regulating therapy （ non-lipid-regulating group ）. The efficacy was compared using the Fugl-Meyer motor assessment （ FMA ）, National Institute of Health Stroke Scale （ NIHSS ）, and Activities of Daily Living （ ADLs ） Scale between the two groups before and after treatment. Results Levels of TC, TG and LDL-C were markedly higher, but HDL-C level was lower in the patients with stroke in the control subjects. Levels of TC and LDL-C were lower in patients with cerebral hemorrhage than in those with cerebral infarction. The hpid-regulating group was superior to the non-lipid-regulating group in the scores on the FMA, NIHSS, and ADLs two months after treatment. Conclusions High levels of TC, TG, and LDL-C and low level of HDL-C are the risk factors for stroke. Proper lipid- regulating therapy can improve the prognosis of patients with stroke.
出处
《国际医药卫生导报》
2012年第11期1624-1627,共4页
International Medicine and Health Guidance News
关键词
脑卒中
调脂治疗
疗效
预后
Stroke
Lipid-regulatingtherapy
Efiicay
Prognosis
