摘要
以缬氨酸氧肟酸为筛选剂 ,对替考拉宁产生菌替考游动放线菌 (Actinoplanes teichomyceticus)进行了推理选育 ,获得了发酵总效价和 TA2 - 2 组分含量均较出发菌株高的缬氨酸氧肟酸抗性变株 98- 1- 2 2 7。传代试验表明菌株 98- 1- 2 2 7的遗传特性较稳定。对菌株 98- 1- 2 2 7和出发菌株 97- 5 - 74的形态、生代特性进行了比较。
Based on the metabolic pathway, a rational selection procedure with valine hydroxamate as a screening agent was performed to obtain a new teicoplanin producing strain Actinoplanes teichomyceticus . By above method, a VH r mutant strain 98 1 227, which is high in both total potency and TA 2 2 titer, was obtained from the parent strain 97 5 74. Subculture test indicated that the hereditary character of strain 98 1 227 was relatively stable. The morphological and biochemical characters between strain 98 1 227 and strain 97 5 74 were compared.
出处
《中国抗生素杂志》
CAS
CSCD
北大核心
2000年第2期94-96,共3页
Chinese Journal of Antibiotics
关键词
替考拉宁
替考游动放线菌
推理选育
Teicoplanin
Actinoplanes teichomyceticus
Valine hydroxamate
Rational selection
