摘要
目的探讨抗双链DNA抗体(抗ds-DNA抗体)与系统性红斑狼疮(SLE)肝损伤的关系。方法选择SLE患者50例,根据抗ds-DNA抗体阳性与阴性将患者分为两组:研究组抗ds-DNA抗体阳性,对照组抗ds-DNA抗体阴性。两组均给予来氟米特片+甲泼尼龙片治疗,观察治疗第2、4、8周时肝功能的变化,并进行统计学分析。结果治疗2周和4周时,两组患者肝功能异常发生率间差异无统计学意义(P>0.05);在治疗第8周时,研究组患者肝功能异常发生率显著高于对照组,差异有统计学意义(P<0.05)。结论在SLE治疗过程中,抗ds-DNA抗体阳性患者较抗ds-DNA抗体阴性患者更易发生肝损伤。
Objective To observe the relationship between anti ds - DNA antibody and liver injury of patients with systemic lupus erythematosus （SLE） . Methods According to the anti ds - DNA antibody positive and negative, 50 eases with SLE were divided into two groups： the anti ds -DNA antibody （ ＋ ） group and the anti ds -DNA antibody （ - ） group. Patients in two groups were both given the leflunomide tablets ＋ methylprednisolone treatment. Then the changes of liver function in two groups were compared at 2 - , 4 - , 8 - week. Results After the treatment of 2 and 4 weeks, there were no statistically differ- enees in the liver injury rate between two groups （P 〉 0. 05 ） . While after 8 - week - treatment, the liver injury rate in patients with anti ds - DNA antibody （ ＋ ） was higher than that of patients with anti ds - DNA antibody （ - ） （ P 〈 0. 05 ） . Conclusion During the treatment of SLE, patients with anti ds - DNA antibody （ ＋ ） are more susceptible to have liver injury, compared with patients with anti ds - DNA antibody （ - ） .
出处
《中国全科医学》
CAS
CSCD
北大核心
2012年第18期2116-2117,共2页
Chinese General Practice
关键词
红斑狼疮
系统性
抗双链DNA抗体
肝损伤
Lupus erythematosus, systemic
Anti ds - DNA antibody
Liver injury
