摘要
目的了解2型糖尿病患者降糖药物用药现状,分析选择药物对血糖控制的影响,为合理治疗提供依据。方法调查入院时2型糖尿病患者群降糖药物使用状况、血糖控制水平及低血糖情况,根据用药情况分为胰岛素组和口服药组,比较胰岛素组和口服药组的血糖控制水平及低血糖的发生率。结果入选288例2型糖尿病患者,平均HbA1c 8.0%,血糖达标率36.8%。胰岛素组和口服药组的空腹血糖、餐后2 h血糖、体质量指数、HbA1c的控制水平相似。胰岛素组的病程明显长于口服药组([11.5±7.0)年vs(8.1±6.0)年],P=0.000)。口服药组的达标率明显优于胰岛素组(43.4%vs 27.0%,P=0.005)。胰岛素组的低血糖发生率高于口服药组(5.2%vs 1.2%,P=0.041)。结论 2型糖尿病患者群血糖达标率低,启动胰岛素治疗迟、超重和低血糖是影响血糖达标重要原因。
Objective To find out the current state of medical treatment of type 2 diabetes mellitus, and to analyze the effect of differ- enl types of medicine on glycemic control, in order to contribute to a proper therapy. Methods The utility of hypoglycemie agents, levels of blood glucose and hypoglycemia among patients admitted by hospital were investigated by categorizing them into two groups, the insulin group and the oral hypoglycemic agents （OHA） group. Results Completed study was obtained in 288 patients, among whom the average HbAIC was 8.0% and total success rate of glycemie control was 36.8%. There were similarities in ages, levels of fasting plasma glucose（FPG）, 2 h plas- ma glucose after meal （2 hPG）, body mass index （BMI） and HbAlc. We could see a longer disease course in insulin group （11.5±7.0 vs. 8.1±6.0, P=0.000） and a higher success rate of glycemic control in OHA group（43.4% vs. 27.0%,P=0.005）, followed by a higher proportion of hypo- glycemia in insulin group （5.2% vs. 1.2%,P=0.041 ）. Conclusion There is a low success rate of glyeemic control in type 2 diabetes popula- tion, while starting insulin treatment late, overweight and hypoglycemia are important causes affecting success rate of glyeemic control.
出处
《安徽医学》
2012年第6期658-660,共3页
Anhui Medical Journal
基金
国家中医临床研究基地重点病种糖尿病建设项目(编号20081211)
关键词
2型糖尿病
口服降糖药
胰岛素
血糖控制
Type 2 diabetes mellitus
Oral hypoglyeemle agents
Insulin
Glycemie control
