摘要
目的研究全麻复合硬膜外麻醉（GEA）对上腹部手术患者围术期机体免疫功能的影响。方法选择60例择期行上腹部手术的患者，随机分为全麻组（GA组）和硬膜外阻滞复合全麻组（GEA组）各30例，两组分别于麻醉前（T1）、麻醉后（T2）、术毕（B）、术后1d（T4）、术后3d（T5）测定外周血T淋巴细胞亚群的变化。结果两组患者T2、T3、T4时点CD3＋、CD4＋及CD4＋／D8＋均较麻醉前下降（P〈0．05），T5时点GEA组各指标恢复接近麻醉前水平，GA组各项指标仍低于麻醉前水平，两组指标相比差异有统计学意义（P〈0．05）。结论GEA对机体免疫功能的影响较小，有利于手术患者的恢复。
Objective To study the influence of general anesthesia combined with epidural anes- thesia on perioperative immune function in patients underwent upper abdominal surgery. Methods To- tally 60 patients underwent upper abdominal surgery were randomly divided into two groups： general an- esthesia combined with epidural anesthesia group （GEA） and general anesthesia group （ GA）, with 30 ca- ses in each group. Peripheral blood T-lymphocyte subsets were measured before induction（T1 ） , after an- esthesia（T2）, at the end of operation（T3） , 1 d（T4）, 3 d（TS） after surgery. Results CD3 ＋ , CD4 ＋ and CD4 ＋/CD8 ＋ all decreased in both groups at T2, T3 and T4, compared with those at T1 （P 〈 0. 05 ）. The indexes almost returned to the baseline values at T5 in GEA group, but the indexes in GA group remained low. There were significant differences between the two groups （P 〈 0.05 ）. Conclu- sions GEA has little influence on immune function, and is good for the recovery of patients.
出处
《中国实用医刊》
2012年第13期42-44,共3页
Chinese Journal of Practical Medicine
关键词
全身麻醉
硬膜外阻滞麻醉
免疫反应
上腹部手术
General anesthesia
Epidural anesthesia
Immune response
Upper abdominal surgery
