摘要
目的观察胸腺五肽在晚期乳腺癌化疗治疗中的疗效。方法将62例晚期乳腺癌患者随机分为胸腺五肽+化疗组(A组)和常规化疗组(B组),分别观察用药前后的血象及治疗前后T细胞亚群变化。结果 A组和B组在化疗前血常规及T细胞亚群均无显著差异(P>0.05),A组治疗后CD3+、CD4+、CD8+与治疗前比较有显著差异(P<0.05),CD4+/CD8+与治疗前比较有显著差异(P<0.05);治疗后白细胞计数在两组之间有显著性差异(P<0.05)。结论胸腺五肽可提高晚期乳腺癌患者的细胞免疫功能。
[ Objective] To observed the efficacy of thymopentin based on chemotherapy on immunologic function in advanced breast cancer in their advanced stage. [ Methods ] Sixty - two patients of advanced breast cancer were divided randomly into routine therapy group and thymopentin therapy group（ To observed the differences of blood routine test result and T Cell Subsets in pre - and post - medication. [ Results ] Before chemotherapy, no visible change in CD3 ＋ ,CD4 ＋ ,CD8 ＋ and the ratio ofCD4 ＋/CD8 ＋ was found in two groups （ P 〉 0.05 ）, After the chemotherapy, CD3 ＋ , CD4＋ and CD8 ＋ of the thymopentin therapy group was significantly different from those before the chemotherapy （ P 〈 0.05 ） ; there is a significant difference between the two groups inWhite Blood Cell Count after treatment （ P 〈 0. 05）. [ Conclusion] The immunologic function is suppressed in the advanced breast cancer patients in their advanced stage, thymopentin may enhanced cellular immunologic functions of the advanced breast cancer patients intheir ad- vanced stage.
出处
《中国医学工程》
2012年第4期30-31,共2页
China Medical Engineering
关键词
晚期乳腺癌
化学治疗
胸腺五肽
免疫功能
advanced breast cancer
chemotherapy
thymopentin
immunologic function
