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绝经前女性乳腺癌辅助内分泌治疗选择策略 被引量:6

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摘要 0引言 我国女性乳腺癌患者50%以上属于绝经前,因为国人乳腺癌发病年龄高峰在45~49岁。虽然绝经前乳腺癌患者激素受体阳性的比例略低(大约60%),但适合选择内分泌治疗病例的绝对数则多于绝经后患者。绝经前女性乳腺癌患者内分泌治疗的主要手段包括雌激素受体选择性调节剂三苯氧胺(tamoxifen,TAM)、卵巢功能抑制(包括手术、放射或药物去势)及卵巢功能抑制联合三苯氧胺,芳香化酶抑制剂(AI)必须联合卵巢去势。它们都是通过降低雌激素水平或阻断雌激素信号通路抑制肿瘤细胞的生长或活性,达到控制肿瘤的目的。
作者 黄平 王晓稼
出处 《肿瘤防治研究》 CAS CSCD 北大核心 2012年第6期623-626,共4页 Cancer Research on Prevention and Treatment
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