摘要
目的分析嗜酸粒细胞性胃肠炎的临床特点、诊断要点及治疗。方法回顾性分析本院2003年1月～2011年8月确诊的22例嗜酸粒细胞性胃肠炎患者的病史、临床表现、实验室检查、内镜检查、病理检查和治疗。结果腹痛为主要症状,20例,占90.91%。血嗜酸粒细胞升高21例,占95.45%,为(3.18±0.97)×109/L。腹水6例,为渗出液,腹水沉渣涂片可见大量嗜酸粒细胞。十二指肠为最常见受累部位,15例,占68.18%。内镜下主要突出表现为黏膜红斑。糖皮质激素治疗2周,所有血嗜酸粒细胞恢复正常;而对症治疗治疗2周,血嗜酸粒细胞无一例恢复正常;两者比较,差异有显著性。结论有胃肠道症状及血嗜酸粒细胞增多的患者,应行胃肠镜检查及在正常和异常部位多点活检。特别注意十二指肠部位活检。明确诊断EG者,糖皮质激素治疗能迅速缓解症状,短时间内使血嗜酸粒细胞恢复正常。
Objective To study the clinical characteristics, diagnosis and treatments of eosinophilic gastroenteritis. Methods The clinical records such as medical history,clinical manifestations, laboratory tests, endoscopic characteristics, histological features, and treatments of 22 patients who were admitted to our hospital from January 2003 to July 2011 and diagnosed as eosinophilic gastroenteritis were reviewed and analyzed. Results Abdominal pain （20 patients,90.91%） was the most common clinical symptom. Peripheral eosinophilia [（3.18 ± 0.97）× 109/L] occurred in 95.45% of patients（21 patients）. Ascitic fluid （6 patients） was an exudate with eosinophils.The duodenum （15 patients,82.4%） was the most common site involved. Erythema was the predominate feature seen on endoscopy. 100% （9/9） of patients treated with corticosteroids had their eosinophil counts return to normal within 2 weeks, but none （0/12） in the patients treated with symptomatic treatment. There is significant difference in the above two treatments. Conclusion Eosinophilic gastroenteritis should be considered in patients who have GI tract symptoms and peripheral eosinophilia. Multiple biopsies obtained from the both normal and abnormal appearing areas are recommended. Biopsy obtained from the duodenum is specially recommended. Symptoms relief and peripheral eosinophil counts rapidly became normal in patients treated with corticosteroids.
出处
《罕少疾病杂志》
2012年第3期5-9,共5页
Journal of Rare and Uncommon Diseases
