期刊文献+

醋酸甲地孕酮对肺癌患者生活质量的影响 被引量:1

原文传递
导出
摘要 目的探讨醋酸甲地孕酮在肺癌化疗中的作用。方法将确诊为肺癌且具有化疗适应证的64例患者,随机分为治疗组和对照组。对照组34例行常规方案化疗,并行常规对症及支持治疗;治疗组30例在对照组治疗的基础上,于化疗当天开始每日口服醋酸甲地孕酮160 mg,连用1周观察患者的食欲、体质量及Karnofskp评分改变并记录不良反应。结果治疗组食欲增加22例,占73.3%;体质量增加18例,占58.9%;Karnofskp评分升高10分以上者16例,占53.3%。对照组食欲增加4例,占11.8%;体质量增加5例,占14.8%;Karnofskv评分升高10分以上者6例,占17.6%,两组比较差异有统计学意义(P<0.05)。结论醋酸甲地孕酮不仅能刺激患者的食欲、增加体质量,改善肺癌患者的生存质量,而且可以减轻化疗所致的胃肠道反应。还可明显减轻化疗的不良反应,提高化疗患者的生活质量,而且不良反应不明显。
出处 《临床医学》 CAS 2012年第3期61-62,共2页 Clinical Medicine
  • 相关文献

参考文献6

  • 1Simons JP,Sehols AM, Hoefnagels JM, et al. Effects of medroxypro- gesterone acetate on food intake, body composition, and resting ener- gy expenditure in patients with advanced, nonhormone-sensitive canc- er: a randomized, placebo-controlled trial [ J ]. Cancer, 1998, 82 (3) :553 -560. 被引量:1
  • 2Fiorica JV, Brunetto VL, Hanjani P, et al. Phase II trial of alterna- ting courses of megestrol acetate and tamoxifen in advanced endometri- al carcinoma: a Gynecologic Oucology Group study[J]. Gynecol On- col, 2004, 92(1): 10-14. 被引量:1
  • 3申桂华,张毅.佳迪对晚期或复发性卵巢癌患者生活质量的影响[J].中国肿瘤临床,2007,34(1):45-47. 被引量:7
  • 4Yeh SS, Wu SY, Lee TP, et al. Improvement in quality-of-life meas- ures and stimulation of weight gain after treatment with megestrol ace- tate oral suspension in geriatric eachexia: results of a double-lind pla- cebo controlled study[J]. J Am Geriatr Soc, 2000, 48(5) :485 -492. 被引量:1
  • 5Mantovni G, Maccio A, Madeddu C, et al. lmmunotherapy (recom- binant interleukin 2 ) , hormone therapy ( medroxyprogesteroae ace- tate) and antioxidant agents as combined maintenance treatment of re- sponders to previous chemotherapy [ J ]. Int J Oncol, 2001 , 18 ( 2 ) : 383 -891. 被引量:1
  • 6Nishimura R, Nagao K, Miyhyama H, et al. An analysis of serum interleukin-6 levels to predict benefits of medroxyprogesterone aee- tate in advanced or recurrent breast cancer[ J]. Oncology, 2000, 59(2) :166 - 173. 被引量:1

二级参考文献11

  • 1王金万,张频,王宏羽,何小慧,谢雅莉,董梅,周际昌,王奇璐,冯奉仪,孙燕.甲孕酮改善化疗患者厌食、体重下降及骨髓抑制作用的临床观察[J].中华肿瘤杂志,1995,17(4):283-285. 被引量:65
  • 2Bruera E, Macmillan K, Kuehn N, et al. A controlled trial of megestrol acetate on appetite, caloric intake, nutritional status, and other symptoms in patients with advanced cancer [J]. Cancer,1990, 66(6): 1279-1282 被引量:1
  • 3Fiorica JV, Brunetto VL, Hanjani P, ct al. Phase Ⅱ trial of alternating courses of megestrol acetate and tamoxifen in advanced endometrial carcinoma: a Gynecologic Oncology Group study[J].Gynecol Oncol, 2004, 92(1): 10-14 被引量:1
  • 4Ruiz Garcia V, Juan O, Perez Hoyos S, et al. Megestrol acetate: a systematic review usefulness about the weight gain in neoplastic patients with cachexia[J]. Med Clin (Barc), 2002, 119(5): 166-170 被引量:1
  • 5Yeh SS, Wu SY, Lee TP, et al. Improvement in quality-of-life measures and stimulation of weight gain after treatment with megestrol acetate oral suspension in geriatric cachexia: results of a double-blind placebo controlled study[J]. J Am Geriatr Soc, 2000,48(5): 485-492 被引量:1
  • 6Gadducci A, Gosio S, Fanucchi A, et al. Malnutrition and cachexla in ovarian cancer patients: pathophysiology and management[J].Antlcancer Res, 2001, 21 (4B): 2941-2947 被引量:1
  • 7Bu SZ, Yin DL, Ren XH, et al. Progesterone induces apoptosis and up-regulation of p53 expression in human ovarian carcinoma cell lines[J]. Cancer, 1997, 79(10): 1944-1950 被引量:1
  • 8Wilailak S, Linasmita V, Srisupundit S. Phase Ⅱ study of highdose megestrol acetate in platinum-refractory epithelial ovarian cancer[J].Anticancer Drugs, 2001, 12(9): 719-724 被引量:1
  • 9Helle SI, Lundgren S, Geisler S, et al. Effects of treatment with megestrol acetate on the insulin-like growth factor system: time and dose dependency[J]. Eur J Cancer, 1999; 35(7): 1070-1075 被引量:1
  • 10Ulutin HC, Arpaci F, Pak Y. Megestrol acetate for cachexia and anorexia in advanced non small cell lung cancer: a randomized study comparing two different doses [J]. Tumori, 2002, 88 (4):277-280 被引量:1

共引文献6

同被引文献4

引证文献1

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部