摘要
目的:了解舟山海岛地区育龄妇女体内有机氯农药的暴露水平,估计研究人群中有机氯农药暴露与新生儿出生缺陷之间的关系。方法:对2007年-2010年舟山市定海区出生缺陷监测资料进行分析。采用气相色谱法检测当地育龄妇女血样中六六六、DDT水平。描述育龄妇女血样中各有机氯农药含量的分布情况,采用秩和检验比较各区域育龄妇女血样中有机氯农药含量的差异,并作各区域出生缺陷发病率与有机氯指标含量之间的等级相关。结果:在血样中各指标的检出率均高于90%,α-HCH、β-HCH、γ-HCH、δ-HCH、p,p'-DDE、p,p'-DDT的检测范围均较低,其总HCH和总DDT的检出范围分别为0.0089 ng/ml～0.6887 ng/ml、0.0071 ng/ml～1.7786 ng/ml。秩和检验结果表明,在不同区域采集的血样标本中有机氯含量比较无统计学意义。将六个区域的出生缺陷发病率与对应区域血清样品中各有机氯指标含量的中位数做Spearman等级相关,结果均未见有统计学显著意义的相关关系。结论:各种有机氯化合物指标在舟山地区育龄妇女血样中的检出率较高,但是没有发现血液中有机氯水平与出生缺陷之间存在统计学的关联,尚需开展进一步的深入研究。
Objective：To understand the organochlorine pesticides exposure levels in women of childbearing age in Zhoushan islands,to study the relationship of organic chlorine levels in women of childbearing age and birth defects.Methods：The data of the birth defects surveillance from Jan.2007 to Dec.2010 in Dinghai district of Zhoushan was analyzed.The concentrations of HCHs and DDTs in plasma of local bearing-age women were detected by gas chromatography.The associations of HCHs and DDTs with birth defects were analyzed.Results：The detectable rates of all components of organic chlorines in plasma were greater than 90%.The detection range of α-HCH,β-HCH,γ-HCH,δ-HCH,p,p＇-DDE and p,p＇-DDT were lower.The total HCH and DDT＇s detectable range were 0.0089 ng/ml～0.6887ng/ml and 0.0071 ng/ml～1.7786 ng/ml respectively.Nonparametric analysis was used for testing organic chlorines in blood of six districts.All organochlorine concentrations were not significantly different among the six districts.The significant correlation of organic chlorines concentration and birth defects was not observed in this study.Conclusion：The detectable rate of organochlorines in the blood samples of Zhoushan area was high,but the organochlorines levels in blood of local bearing-age women were not significantly correlated with the prevalence of birth defects.
出处
《中国卫生检验杂志》
北大核心
2012年第6期1301-1304,共4页
Chinese Journal of Health Laboratory Technology
基金
浙江省医药卫生科技计划项目(05B07)
浙江省社会发展公益类项目(2009C33135)
关键词
海岛地区
育龄妇女
出生缺陷
有机氯农药
Island area
Women of childbearing age
Birth defects
Organochlorine pesticides
