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miRNAs联合CA19-9对胰腺癌的诊断效能 被引量:3

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摘要 目的研究血清miRNAs(miR-16)联合CA19-9对胰腺癌的诊断效能。方法收集45例慢性胰腺炎患者、45例胰腺癌患者和30例健康人作对照,采用实时逆转录-多聚酶链反应方法检测血浆miR-16表达水平和临床检测糖链抗原19-9(CA19-9),分析miR-16、CA19-9及其二者联合对胰腺癌的诊断效能。结果 miR-16在血浆中含量胰腺癌>慢性胰腺炎(P<0.05),慢性胰腺炎组与健康对照组差异无统计学意义;miR-16联合CA19-9与miR-16、CA19-9单独诊断比较,miR-16与CA19-9联合可显著提高诊断胰腺癌的敏感性和特异性,LR+均>20,LR-均<0.2。结论 miR-16联合CA19-9可提高胰腺癌的诊断效能。
出处 《军医进修学院学报》 CAS 2012年第7期772-774,共3页 Academic Journal of Pla Postgraduate Medical School
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