摘要
[目的]探讨磷酸化胰岛素样生长因子结合蛋白-1（IGFBP-1）检查在隐匿型胎膜早破中的诊断价值.[方法]选择隐匿型胎膜早破孕妇74例,检测孕妇宫颈阴道分泌物中IGFBP-1、pH值、羊齿状结晶,比较三种方法的敏感度、特异度、诊断符合率、阳性和阴性预测值.[结果]隐匿型胎膜早破孕妇74例中,IGFBP-1检测的敏感性、特异性、阳性预测值、阴性预测值及诊断符合率分别为94.4%、85.0%、94.4%、85.0%和91.8%;pH值检测分别为87.0%、80.0%、92.2%、69.0%和85.1%;羊齿状结晶法检测分别为83.3%、80.0%、91.8%、64.0%和82.4%,IGFBP-1检测敏感性、特异性、阳性预测值、阴性预测值及诊断符合率均显著高于pH值及羊齿状结晶检测法,其差异有统计学意义（P〈0.05）.[结论]IGFBP-1可提高隐匿性胎膜早破的诊断率,值得临床推广.
[Objective] To explore the value of dephosphorylation IGFBP-1 detection in the diagnosis of oc-cult premature rupture of membranes. [Methods] Totally 74 pregnant women with occult premature rupture of membranes were chosen. IGFBP-1, PH value and arborisation in Cervix vaginal secretions of pregnant women were measured. The sensitivity, specificity, diagnosis coincidence rate, positive and negative predictive value were compared among three methods. [Results] Among 74 pregnant women with occult premature rupture of membranes, the sensitivity, specificity, positive and negative predictive value and diagnosis coincidence rate of IGFBP-1 detection were 94.4%, 85.0%, 94.4%, 85.0% and 91.8%, respectively, and those of PH value were87.0%, 80.0%, 92. 2%, 69. 0% and 85. 1%, respectively, and those of arborisation were 83. 3%, 80.0%, 91.8%, 64.0% and 82.4%, respectively. The sensitivity, specificity, positive and negative predic-tive value and diagnosis coincidence rate of IGFBP-1 detection were obviously higher than those of PH value and arborisation detection method, and there were significant differences（ P 〈0.05）. [Conclusion] IGFBP-1 can improve the diagnosis rate of occult premature rupture of membranes, and is worthy of clinical application.
出处
《医学临床研究》
CAS
2012年第5期823-824,827,共3页
Journal of Clinical Research
关键词
胎膜早破/诊断
胰岛素样生长因子结合蛋白质1
Fetal membranes,premature rupture/Di
insulin-like growth-factor binding protein 1
