摘要
目的观察地尔硫卓联合曲美他嗪治疗不稳定心绞痛的临床疗效及安全性。方法选取46例不稳定心绞痛患者随机分为地尔硫卓联合曲美他嗪治疗组和对照组各23例,对照组常规给予硝酸酯类,β-受体阻滞剂,阿司匹林,氯吡格雷及他汀类药物,治疗组在此基础上加用地尔硫卓和曲美他嗪。比较两组间心绞痛发作次数,持续时间,心电图,血压,心率变化情况。结果地尔硫卓联合曲美他嗪治疗组较对照组心绞痛发作次数减少,持续时间缩短(P<0.05),心电图回落明显(P<0.05);同治疗前比较,两组均血压下降,心率减慢(P<0.05);治疗后两组间比较心率、血压无明显差异(P>0.05)。结论地尔硫卓联合曲美他嗪治疗不稳定心绞痛临床疗效佳,安全性高,值得临床推广应用。
Objective To observe the clinic effect and safety of diltiazem combined trimetazidine in the treatment of unstable angina.Methods Forty six cases of unstable angina were randomly divided into two groups： control group and treatment group.The control group was given conventional nitrates,β-blockers,aspirin,clopidogrel and simvastatin;on the basis of these,treatment group was additionally given diltiazem and trimetazidine.The numbers of angina attacking,duration,ECG,blood pressure and heart rates were compared between the two groups.Results Compared with the control group,in the diltiazem combined trimetazidine treatment group,the number of angina attacking reduced,duration shortened（P0.05）,ECG dropped significantly（P0.05）;heart rates of both groups reduced,blood pressure dropped than that before the treatment（P0.05）;after treatment,the heart rates,blood pressure was no significant difference between the two groups（P0.05）.Conclusion Diltiazem combined trimetazidine has a good clinical efficacy and high safety in treatment of unstable angina.It is worthy of clinical application.
出处
《中华全科医学》
2012年第7期1061-1063,共3页
Chinese Journal of General Practice
