摘要
目的观察甘草酸二胺佐治慢性乙型肝炎活动期的临床疗效及用药安全性。方法随机将92例慢性乙型肝炎活动期患者依据住院单双日分为观察组和对照组各46例,入院后两组给予同样的护肝治疗和对症支持处理,观察组加用甘草酸二胺150mg静脉滴注,对照组加用门冬氨酸钾镁20ml静脉滴注,均1次/d,疗程14d。结果观察组临床症状体征改善、肝功能恢复情况均明显优于对照组(P<0.05);两组HBV标记物HBeAg、HBV-DNA阴转率比较,差异无统计学意义(P>0.05);两组副作用均不明显。结论在常规综合护肝治疗的基础上,甘草酸二胺佐治慢性乙型肝炎活动期能较好改善临床症状,促进肝功能恢复,用药较安全。
Objective To observe the effect and safety of using diammonium glycyrrhizinate to treat the chronic hepatitis B during its active stage. Meihods 92 cases with chronic hepatitis B in the active stage were randomly divid- ed into the observation group and the control group with 46 cases in each group. Both groups were given routine livertreatment, on the basis of which the observation group were given 150 mg intravenous infusion of diammonium gly- cyrrbizinate,the control group were given 20 ml intravenous infusion of potassium magnesium, once a day and 14 days as a treatment course. Results The observation group had much better improvement of clinical symptoms,signs and liver function than the control group（ P 〈0.05）. The groups had no statistical difference in the seroconversion rates of HBV markers, HbeAg, HBV DNA（ P 〉0.05）. The side effects of both groups were not obvious. Conclu- sion On the basis of routine comprehensive liver protecting therapy,adding diammonium glycyrrhizinate to treat chronic hepatitis B in the active stage can improve clinical symptoms, recovery of liver function and the medication safety.
出处
《右江医学》
2012年第3期331-333,共3页
Chinese Youjiang Medical Journal
关键词
甘草酸二胺
慢性乙型肝炎
活动期
diammonium glycyrrhizinate
ehronic hepatitis B
the active stage
