摘要
B型RAF基因（BRAF）编码蛋白质的第600位密码子对应的缬氨酸被谷氨酸替代（BRAF^V600E突变）是甲状腺乳头状癌中最常见的基因突变。很多研究表明，该突变与甲状腺乳头状癌的发生、发展和转移密切相关。该文综合阐明BRAPm突变在甲状腺乳头状癌中的术前诊断、预后判断和抑制剂治疗等方面的临床应用，以便更好地指导临床决策。
Valine（V） being substituted for by glutamate（E）at codon 600 in B type RAF gene （BRA Fv~~E mutation ）is the most common genetic mutation in papillary thyroid cancer. There have been many researches shown a strong association between BRA Fv600E mutation and the occurrence, progression and metastasis of papillary thyroid cancer. This article illustrates its clinical utility on the preoperative diagnosis, prognosis evaluation and inhibitor treatment of papillary thyroid cancer, so as to instruct the clinical management better.
出处
《国际放射医学核医学杂志》
2012年第2期84-87,共4页
International Journal of Radiation Medicine and Nuclear Medicine
