摘要
目的观察辛伐他汀对稳定性心绞痛伴高血脂患者的量效关系及其安全性。方法将100例稳定性心绞痛伴高血脂患者,前瞻性的随机分为A、B两组,每组各50例,在稳定性心绞痛常规治疗的基础上,A组给予辛伐他汀每天20mg治疗,B组每天给予80mg治疗,治疗12周后观察治疗前后血脂及心绞痛的改善情况,并观察患者的不良反应。结果治疗后A、B两组血脂及心绞痛均得到显著改善(P<0.01),而TC、LDL-C的改善,B组优于A组(P<0.01);8周后两组开始出现明显的不良反应,B组出现更多,但均未出现严重不良事件。结论应用大剂量辛伐他汀药物能提高稳定性心绞痛伴高血脂患者的疗效,在8周内使用较为安全。
Objective To observe the does-effect and safety of simvastatin in treating stable angina with hyperlipi- demia. Methods 100 cases with stable angina with hyperlipidemia were randomly divided into two groups （n= 50）, on the basis of routine treatment. Group A were treated with 20mg does simvastatin per day, and group B with 80mg does simvastatin per day. Adverse reactions were recorded during treatment, and the clinical effects of blood lipid and angina were compared between group A and B before and after 12 weeks treatment. Results For clinical effects, as well as TC, LDL-C, both group achieved significant effect after 12 weeks treatment （P〈0.01）, Group B was more notable than group B （P〈0. 01）. Adverse effects emerged evidently after 8 weeks, especially in group B. Conclusion Higher does simvastatin can improve the therapeutic effect in stable angina with hyperlipidemia. It may be much safer in 8 weeks treatment.
出处
《西部医学》
2012年第6期1117-1118,共2页
Medical Journal of West China
