摘要
目的:探讨参附注射液(Shenfu Injection,SFI)对实验性慢性心力衰竭(chronic heart failure,CHF)大鼠心脏的保护作用。方法:采用腹主动脉缩窄法制作心衰大鼠模型,观察不同剂量的参附注射液及依那普利对慢性心力衰竭的作用。结果:参附高剂量组LVSP水平显著增高,心肌组织中Ang-Ⅱ、ET、IL-6、TNF-α的含量显著降低。结论:参附注射液能显著改善实验性慢性心力衰竭大鼠血流动力学状态,增强左室的射血功能,降低心衰大鼠心肌组织中Ang-Ⅱ、ET、IL-6、TNF-α的含量,其作用优于依那普利。
Objective： To investigate Shenfu Injection on protective function of congestive heart failure in rats. Method： Established congestive heart failure model of rats by coarctation of abdomial aorta. Observed the effects between the Shenfu Injection in different dosages and Enalaprol on chronic heart failure. Resuh：In the Shenfu - haper - dosage group, the LVSP Level of ventricle was increased evidently, and the contents of Ang - II , ET, IL - 6, TNF - et notably were decreased （ P 〈 0.01）. Conclusion：The experimental result proves that Shenfu injection can notably ameliorate the hemodynamics and the pathological constitution of experimental chronic congestive heart failure of rats and notably decrease the contents of IL - 6, ET, TNF - α, Ang - II from myocardium tissue of experimental chronic congestive heart failure, and improve myocardial function, it＇ s effect surpass the Enalapril.
出处
《现代临床医学》
2012年第3期173-175,共3页
Journal of Modern Clinical Medicine
