摘要
IL-17作为前炎症因子参与类风湿关节炎,系统性红斑狼疮等自身免疫性疾病的病理过程。它主要由CD4+T细胞的一个亚群--Th17细胞分泌释放。目前,IL-17在类风湿关节炎的病理过程中的作用引起了医学界广泛的关注,抗IL-17A抗体已经生产并进入临床实验,用于治疗类风湿关节炎、银屑病关节炎等疾病。但其在类风湿关节炎病理过程中的作用尚需进一步研究,其有效性亦尚需进一步探讨。本文主要针对IL-17家族的各个亚型的表达、调控、生物学作用及与类风湿关节炎发病的关系进行阐述,为类风湿关节炎的治疗提供新的思路。
IL-17 is a pro-inflammatory factor which is involved in autoimmune diseases,such as rheumatoid arthritis and systemic lupus erythematosus.It is mainly released by Th17 cell-a subtype of CD4＋T cell.At present,the effect of IL-17 on the patholagical process of rheumatoid arthritis has been widely paid attention attention.Anti-IL-17A antibodies,which are used for the treatment of rheumatoid arthritis,psoriatic arthritis and other diseases,have been produced and entered clinical trials.But the role of IL-17 on pathological processes still needs to be further studied,and its effects also need to be further investigated.This article mainly reviews the expression,regulation,biological functions of the IL-17 family and the relationship with rheumatoid arthritis to supply new ideas to the treatment of rheumatiod arthritis.
出处
《现代生物医学进展》
CAS
2012年第15期2971-2973,共3页
Progress in Modern Biomedicine
