摘要
目的:观察急性肾损伤(Acute kidney injury,AKI)患者血清胱抑素-C(Cystatin-C,CysC)及尿中性粒细胞明胶酶相关脂质运载蛋白(Neutrophil gelatinase-associated lipocalin,NGAL)水平的变化及其临床意义。方法:选择60例AKI患者为实验组,50例正常健康人作为对照组,应用酶联免疫吸附法测定两组人群血清胱抑素-C和尿NGAL水平。结果:实验组与对照组相比血清胱抑素-C和尿NGAL水平显著升高,差异有统计学意义(P<0.05)。实验组尿NGAL检出率高于血清胱抑素-C、血肌酐,差异有统计学意义(P<0.05)。结论:急性肾损伤患者血清胱抑素-C和尿NGAL均升高,其中尿NGAL是反映AKI较敏感的生物学标志物,值得临床进一步研究。
Objective： To observe the serum cystatin-C（CysC） and the urinary neutrophil gelatinase-associated lipocalin（NGAL） level of the patients of the acute kidney injury（AKI） and to assess its clinical significance.Methods： We chose 60 patients of AKI as the experimental group,and 50 healthy people as thecontrol group.The serum cystatin-C and urinary NGAL levels of two groups were detected by enzyme-linked immunosorbent assay.Results： Compared with the control group,theserum cystatin-C and urinary NGAL levels significantly increased,and the differences were statistically significant（P 0.05）.The urinary NGAL detection rate was higher than serum cystatin-C,serum creatinine of experimental group,and the difference was statistically significant（P 0.05）.Conclusion： Theserum cystatin-C and urinary NGAL of the patients of AKI were both increased,and the urinary NGAL was a more sensitive than the serum cystatin-C,and it is worthy studying further.
出处
《现代生物医学进展》
CAS
2012年第15期2943-2945,共3页
Progress in Modern Biomedicine
