摘要
多年来，合并器质性心脏病室性心律失常的治疗一直是心血管疾病领域面临的重大挑战。传统抗心律失常药物潜在的心脏抑制作用及脏器毒性作用限制了其长期应用。因此仅在室性心律失常已发生后再进行干预的下游治疗是远远不够的．还必须对心律失常形成的基质进行干预．即上游性治疗。室性心律失常发生的基质是局部心肌存在氧化应激、
出处
《实用医学杂志》
CAS
北大核心
2012年第11期1916-1918,共3页
The Journal of Practical Medicine
基金
北京市自然科学基金资助项目(编号:7092023)
北京市卫生系统高层次卫生技术人才培养项目(编号:2009-2-01)
参考文献24
-
1Ravens U. Novel pharmacological approaches for antiarrhythmic therapy[J].Naunyn-Schmiedeberg's Archives of Pharmacology,2010,(03):187-193. 被引量：1
-
2Das M K,Zipes D P. Antiarrhythmic and nonantiarrhythmic drugs for sudden cardiac death prevention[J].Journal of Cardiovascular Pharmacology and therapeutics,2010,(05):438-449. 被引量：1
-
3Teo K K,Mitchell L B,Pogue J. HOPE Investigators.Effect of ramipril in reducing sudden deaths and nonfatal cardiac arrests in high-risk individuals without heart failure or left ventricular dysfunction[J].Circulation,2004,(11):1413-1417. 被引量：1
-
4Askari A T,Shishehbor M H,Kaminski M A. The association between early ventricular arrhythmias,renin-angiotensin-aldosterone system antagonism,and mortality in patients with ST-segment-elevation myocardial infarction;Insights from global use of strategies to open coronary arteries (GUSTO) V[J].American Heart Journal,2009,(02):238-243. 被引量：1
-
5Dulak E,Lubifiski A,Bissinger A. Recurrence of ventricular arrhythmias in patients with non-ischaemic dilated cardiomyopathy:evidence-based predictors[J].Kaldiol Pol,2009,(08):837-844. 被引量：1
-
6Iravanian S,Dudley S C Jr. The renin-angiotensin-aldosterone system (RAAS) and cardiac arrhythmias[J].Heart Rhythm,2008,(6 Suppl):S12-S17. 被引量：1
-
7Shang L L,Sanyal S,Pfahnl A E. NF-KB-dependent transcritional regulation of the cardiac scn5a sodium channel by angiotensin II[J].American Journal of Physiology-Cell Physiology,2008,(01):C372-C379. 被引量：1
-
8Stein M,Boulaksil M,Jansen J A. Reduction of fibrosis-related arrhythmias by chronic renin-angiotensin-aldosterone system inhibitors in an aged mouse model[J].American Journal of Physiology-Heart and Circulatory Physiology,2010,(02):H310-H321. 被引量：1
-
9阳元彬,马康华.心肌梗死后连接蛋白43重构与室性心律失常[J].实用医学杂志,2009,25(2):327-329. 被引量：1
-
10Iravanian S,Xiao H D,Witham E A. Abstract 1088:Prevention of connexin 43(cx43) dephosphorylation is associated with reduced ventricular tachycardia in cardiac-specific angiotensin converting enzyme (ACE) overexpression mice[J].Circulation,2007.II_218. 被引量：1
二级参考文献33
-
1Sohl G, Willecke K. Gap junctions and the connexin protein family [J]. Cardiovasc Res, 2004,62 (2) : 228-232. 被引量：1
-
2Peters N S, Coromilas J, Severs N J, et al.Disturbed connexin43 gap jun-ction distribution correlates with the location of reentrant circuits in the epicardial border zone of healing canine infarcts that cause ventrieular tachycardia [J]. Circulation, 1997,95 (4) : 988 -996. 被引量：1
-
3Lindsey M L, Escobar G P, Mukher jee R, et al. Matrix metalloproteinase-7 affects connexin-43 levels,electrical conduction, and survival after myocardial infarction [J]. Circulation, 2006, 113 (25) : 2919- 2928. 被引量：1
-
4Amino M, Yoshiokak K, Tanable T, et al. Heavy ion radiation up-regulates Cx43 and ameliorates arrhythmogenic substrates in hearts after myo-cardial infarction [J]. Cardiovase Res, 2006,72(3) :412-421. 被引量：1
-
5Yao J A, Hussain W, Patel P, et al. Remodeling of gap junctional channel function in epicardial border zone of healing canine infarcts [J]. Circ Res, 2003,92 (4) : 437 -443. 被引量：1
-
6Li W E, Nagy J I. Connexin43 phosphorylation state and intercellular communication in cultured astrocytes following hyoxia and protein phosphatase inhibition [J]. Eur J Neurosci, 2000, 12 (7) :2644-2650. 被引量：1
-
7Ruch R J, Trosko J E, Madhukar B V. Inhibition of connexin43 gap junctional intercellular communication by TPA requires EKP activation [J]. Cell Biochem, 2001,83 ( 1 ) : 163-169. 被引量：1
-
8Fischer R, Dechend R, Gape|yuk A, et al. Angiotensin Ⅱ-induced sudden arrhythmic death and electrical remodeling [J]. Physiol Heart Circ Physiol, 2007, 293(2) : 1242-1253. 被引量：1
-
9Ando M, Katare R G, Kakinuma Y, et al. Efferent vagal nerve stimulation protects heart against ischemia-induced arrhythmias by preserving connexin43 protein [J]. Circulation, 2005,112(2) : 164-170, 被引量：1
-
10Zhang Y, Kakinuma Y, Ando M, et al. Acetylcholine inhibits the hypoxia induced reduction of connexin43 protein in rat cardiomyocytes [J]. Pharmacol Sci, 2006,101(3):214-222. 被引量：1
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-
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-
2蒋文平.室性心律失常药物治疗选择[J].中华心血管病杂志,2006,34(10):956-960. 被引量：30
-
3黄永麟.室性心律失常的临床处理策略[J].中华心血管病杂志,2007,35(11):1070-1072. 被引量：45
-
4WYSE DG,WALDO AL,DIMAREO JP. A comparison of rate control and rhythm control in patients with atrial fibrillation[J].New England Journal of Medicine,2007,(23):1825-1833. 被引量：1
-
5张常群.地高辛与美托洛尔合用治疗房颤伴快速心室率疗效观察[J].山东医药,2010,50(12):49-50. 被引量：8
-
6韩延辉.老年慢性心力衰竭并发心律失常90例临床分析[J].中国老年学杂志,2011,31(24):4911-4912. 被引量：18
-
7刘熠.稳心颗粒联合比索洛尔治疗扩张型心肌病心律失常疗效观察[J].辽宁中医杂志,2012,39(2):305-306. 被引量：8
-
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-
2曹克将,张澍.关注器质性心脏病室性心律失常的临床研究[J].中华心律失常学杂志,2013,17(1):7-8. 被引量：2
-
3黄绍烈,胡大一,杨明,张宝娓,丁燕生.无临床器质性心脏病室性心律失常心室晚电位的检测及预后随访[J].江西医学院学报,1998,38(2):16-16.
-
4盖鲁粤,任艺虹.慢性心力衰竭的药物治疗[J].中国循环杂志,2004,19(6):401-401. 被引量：2
-
5李光伟.2型糖尿病胰岛素治疗的思考[J].中国社区医师,2008,24(10):22-22. 被引量：1
-
6胡大一,仝其广.中国胆固醇教育计划(CCEP)系列讲座(十二) 强化降脂 防治冠心病[J].中华医学信息导报,2005,20(19):14-14.
-
7杨震,贾绍斌,王学忠,沙勇.急性心肌梗死合并心源性休克的诊断及治疗进展[J].心血管病学进展,2012,33(6):763-767. 被引量：23
-
8曾怡,郭立新.糖尿病患者低血糖亟待关注[J].中华糖尿病杂志,2017,9(3):145-147. 被引量：4
-
9翁梅芳,吴子珍,唐继志.心脏病室性心律失常患者Tp-e间期、Tp-e/Q-T比值的研究[J].心脑血管病防治,2012,12(2):91-93. 被引量：7
-
10李晓贞.734例肺结核患者的耐药情况分析[J].中国医药指南,2015,13(17):163-163. 被引量：1
