摘要
用大鼠在体肺灌流和雪貂左下肺叶活体灌流方法比较了川芎嗪对缺氧、血管紧张素Ⅱ、高钾、almitrine等所致肺血管收缩的舒张效应。实验结果表明,川芎嗪能使缺氧引起的收缩肺血管明显舒张,此效应可能不通过血管紧张素系统。对高钾引起的肺血管收缩,川芎嗪的抑制作用明显小于异搏定。川芎嗪对肺血管的舒张效应表明缺氧和almitrine对肺血管的作用相近。在急性缺氧情况下,川芎嗪对肺血管的舒张作用比对体血管强,这一点对缺氧性肺动脉高压的防治是很有用的。
The action of ligustrazine on the pulmonary circulation was tested in isolated perfused rat lung and autoperfused ferret left lower lobe preparation in vivo. Ligustrazine reduced hypoxic pulmonary vasoconstriction in a dose-dependent manner. It had a lesser dilator effect on KCl-induced vasoconstriction than verapamil and a relatively mild inhibitory effect on the pressor response to angiotensin Ⅱ. Ligustrazine preferentially inhibited the vasoconstriction caused by hypoxia and almitrine. The increased slope and intercept of pressure-flow curve caused by hypoxic vasoconstriction were reduced to the normal range after administration of ligustrazine(4mg). Thus ligustrazine proved to be a powerful pulmonary vasodilator. It had a relatively mild depressor effect on systemic blood pressure.
出处
《中国应用生理学杂志》
CAS
CSCD
1990年第1期19-22,共4页
Chinese Journal of Applied Physiology
关键词
川芎嗪
缺氧性
肺血管收缩
鼠
雪貂
ligustrazine
hypoxic pulmonary vasoconstriction
isolated perfused rat lung
au- toperfused left lower lobe of ferret lung.
