摘要
目的:分析β-catenin在乳腺癌组织中的表达特点及与预后的关系,以寻找新型的乳腺癌预后标志。方法:用组织芯片及免疫组织化学的方法检测β-catenin在213例乳腺癌组织中的表达,采用ROC曲线确定β-catenin表达高低的分界值,采用单变量及多变量分析β-catenin表达与乳腺癌预后的关系。结果:213例乳腺癌患者中,71.4%(152/213)为β-catenin高表达,28.6%(61/213)为β-catenin低表达;单变量分析显示,β-catenin高表达的患者总生存率(P=0.003)、无进展生存率(P=0.040)及无远处转移生存率(P=0.024)均低于β-catenin低表达的患者;多变量分析显示,β-catenin与乳腺癌患者总生存率(RR=5.961,95%CI:0.238～0.855,P=0.015)和无远处转移生存率(RR=3.888,95%CI:0.269～0.996,P=0.049)相关。结论:乳腺癌患者中β-catenin呈高表达,且表达越高预后越差。β-catenin可作为判断乳腺癌预后的一个新型、独立的指标。
OBJECTIVE： To investigate the expression of β-catenin in breast cancer tissue and correlation with prognostic and several clinicopathological factors and find an novel prognostic factor. METHODS： Immunohistochemistry for β-catenin were performed on a tissue microarry （TMA） of 213 cases breast carcinoma. Receiver-operating characteristic （ROC） curve analysis was used to determine cutoff scores for tumor β-catenin positive expression. Both univariate and multivariate analysis were used to determine the relation between β-catenin expression and clinical outcome. RESULTS： Patient with ROC-derived β-catenin cutoff score of 6 successfully segregated into low （61/213, 28. 6%） and high （152/213,71. 4%）β-catenin expression subgroups. Univariate analysis showed that high expression of β-catenin was strongly related to patients with poorer overall survival （P=0. 003） ,distant metastasis-free survival （P=0. 024） and progression-free survival （P = 0. 040）. Similarly, multivariate analysis demonstrated β-eatenin expression （RR = 5. 961, 95%CI：0. 238-0. 855,P=0. 015;RR=3. 888,95%CI：0. 269-0. 996,P=0. 049） was evaluated as an independent pa- rameter. CONLUSIONS： The expression of β-catenin is increased in the breast cancer,and the high expression of β-catenin is related to a poor result of breast cancer, So β-catenin is an novel independent prognostic marker for breast cancer patients.
出处
《中华肿瘤防治杂志》
CAS
北大核心
2012年第10期753-756,共4页
Chinese Journal of Cancer Prevention and Treatment
基金
广东省卫生厅资助项目(303041146001)
