摘要
背景与目的原发性肺肉瘤(primary pulmonary sarcoma,PPS)是一种极少见的肺部原发性恶性肿瘤,起源于肺间叶组织,极易误诊,本研究旨在探讨原发性肺肉瘤的临床特点,以期为临床早期诊断及治疗提供更全面的参考依据。方法分析总结四川大学华西医院1996年-2011年经病理证实的19例PPS患者的临床资料并进行文献复习。结果 19例患者中男性12例,41岁-68岁患者占57.9%,平均年龄41岁。主要症状为咳嗽、咳痰以及咯血;影像学表现中8例见"毛刺征",5例见"分叶征",主要病理学类型为滑膜肉瘤、平滑肌肉瘤以及恶性纤维组织细胞瘤。手术治疗17例,化疗1例。随访17例,随访率89.5%,中位生存时间为18个月。结论原发性肺肉瘤临床及影像学均无特征性表现,易被误诊,死亡率高。
Background and objective Primary pulmonary sarcoma （PPS） is a rare malignant tumor that originates from the mesenchymal tissue of the lungs. PPS is often easily misdiagnosed. This study aims to explore the clinical character- istics of PPS and provide a more comprehensive reference for the early diagnosis and treatment of this disease. Methods The 1996 to 2011 clinical data of 19 cases with PPS in West China Hospital were presented, along with literature review. Results A total of 19 patients, which include 12 males, were presented in this study. Patients with age between 41 and 68 years accounted for S7.9% （the mean age was 41 years）. The main clinical manifestations were cough, expectoration, and hemoptysis. Based on the imaging results, spiculation was found in eight cases and lobulation in five cases. The main pathologic types were synovial sarcoma, leiomyosarcoma, and malignant fibrous histiocytoma. Seventeen patients underwent surgery, whereas one patient underwent chemotherapy. All 17 cases with a median survival of 18 months were investigated after being discharged （follow-up rate： 89.5%）. Conclusion The clinical and imaging features of PPS are not characteristic. Thus, PPS is easily misdiagnosed and can cause high mortality among patients.
出处
《中国肺癌杂志》
CAS
北大核心
2012年第6期375-380,共6页
Chinese Journal of Lung Cancer
关键词
原发性肺肉瘤
诊断
治疗
Primary pulmonary sarcoma
Diagnosis
Treatment
