摘要
目的在回顾性分析99例非小细胞肺癌骨转移病例临床特征。方法番禺区中心医院肿瘤科2004年7月～2008年7月收治的所有非小细胞肺癌骨转移病例。结果符合条件的临床病例共99例,中位生存时间8.3月(1.4月～38.5月)。43例(43.4%)发生骨相关事件。化疗后发生骨转移的患者更常见发生骨相关事件(P=0.020),使用唑来膦酸可能减少骨相关事件的发生(P=0.075)。单因素分析显示,PS状态(P=0.049)、是否发生骨相关事件(P=0.001)影响生存。Cox回归多因素分析显示,影响非小细胞肺癌骨转移患者预后的独立因素为是否合并肝转移(P=0.044)、是否发生骨相关事件(P=0.000)。既往曾行肺原发灶放疗患者预后可能较好(P=0.085)。结论早期发现、早期诊断骨转移并使用唑来膦酸可能可以减少非小细胞肺癌骨相关事件的发生并改善预后。
Objective To retrospectively analyze the clinical features of skeletal metastases in 99 non-small cell lung cancer patients. Methods All the pathologically diagnosed non-small cell lung cancer patietns with skeletal metastasis from July 2004 to July 2008 in Panyu District Central Hospital were investigated. Results A total of 99 patients were found to have skeletal metastases during their clinical course and 43 patients（43.4%） out of these 99 patients had SREs.The median survival time was 8.3 months（1.4 to 38.5 months）.SREs was obseved in most patients treated with chemotherapy before the diagnosis of skeleton metastasis（P=0.020） and use of zoledronic acid may reduce the occurrence of SREs（P=0.075）.The Performance Status（PS）（P=0.049）,the SREs（P=0.001） affected the survival.Cox regression multivariate analysis showed that the survival of patients was associated with liver metastases（P=0.044）,and the SREs（P=0.000）.The prognosis of patients who previously had radiation therapy of pulmonary primary tumor may be better（P=0.085）.Conclusions Early detection,early diagnosis of skeletal metastases and the use of zoledronic acid may reduce the occurrence of SREs of non-small cell lung cancer and improve the prognosis.
出处
《中国热带医学》
CAS
2012年第4期514-516,518,共4页
China Tropical Medicine
关键词
骨转移
骨相关事件
非小细胞肺癌
Skeletal metastasis
Skeletal-related event
Non-small cell lung cancer
