摘要
目的探讨肺表面活性物质(PS)治疗新生儿呼吸窘迫综合征(NRDS)的临床疗效。方法观察组30例NRDS患儿给予气管内滴注单剂PS治疗,对照组22例未给予PS治疗,其余治疗两组相同。结果观察组早期应用PS后,患儿临床症状明显改善,动脉血氧分压(PaO2)和动脉/肺泡血氧分压比值(a/APO2)明显上升,氧合指数(OI)值明显下降,改善程度好于对照组(P<0.01)。床旁胸部X线片显示,与对照组比较,观察组改善更快,效果更好(P<0.01),对机械通气和氧疗的需求显著降低(P<0.05)。结论 PS对NRDS疗效满意,能提高患儿的生存质量,值得推广。
Objective To study the clinical effect of early pulmonary surfactant（PS） in the treatment of neonatal respiratory distress syndrome（NRDS）.Methods The observation group（30 cases of NRDS） was treated with single dose of PS by intratracheal administration,while the control group（22 cases of NRDS） did not receive PS treatment.The other treatment was same in the two groups.Results After administration of early PS,the clinical symptoms in the observation group were relieved markedly,the values of arterial partial pressure of oxygen（PaO2） and arterial oxygen/alveolar oxygen ratio（a/A PO2） were significantly increased and the oxygen index（OI） was obviously decreased.The improvement degree in the observation was better than that in the control group（P0.01）.Bedside X ray imaging showed that the observation group was improved faster and better compared with the control group（P0.01）.The demand for mechanical ventilation and oxygen therapy in the observation group was cut down notably as compared to the control group（P0.05）.Conclusion PS replacement therapy for NRDS has satisfactory therapeutic effect and raises the patients′ survival quality,which is worthy of wide spread application in clinic.
出处
《现代医药卫生》
2012年第10期1467-1468,共2页
Journal of Modern Medicine & Health
关键词
呼吸窘迫综合征
新生儿
肺表面活性剂
治疗结果
Respiratory distress syndrome
newborn
Pulmonary surfactants
Treatment outcome
