摘要
目的 :建立金黄地鼠诱发性舌癌模型 ,并观察颈淋巴结转移。方法 :通过二甲基苯并蒽 (DMBA)涂抹金黄地鼠舌粘膜的同时分别使用刺破粘膜和切割诱发肿瘤 ,每周二次 ,共 2 5周 .结果 :涂药组成瘤率 95 % ( 3 8 4 0 ) ,动物均经历了上皮异常增生、原位癌、浸润癌和转移癌几个阶段 ,3只实验组金黄地鼠出现颈淋巴结转移。组织学呈高分化鳞状细胞癌表现。结论 :DMBA能诱发金黄地鼠舌癌形成 。
Objective: To establish the induced tongue carcinoma model in Syrian golden hamster and its cervical lymphnode metastasis. Methods: 5%7,12-dimethylbenzanthrancene(DMBA)in aceton was applied to the right tongue border of golden Syrian hamster followed by scrapping and incision, twice a week, lasting 25weeks. Results: The carcinogenesis-rate was95%(38/40)in DMBA group,3 of 40 had the lymph node metastasis, they had hyperplasia of epithelium cell、carcinoma in situ、invasive carcinoma and metastatic carcinoma four stages, Histologically they were high-differentiated squamous cell carcinoma. Conclusion: DMBA could induce tongue carcinogenesis and incision could increase cervical lymphnode metastasis [
出处
《口腔医学纵横》
CAS
CSCD
2000年第1期10-12,共3页
Journal of Comprehensive Stomatology
关键词
动物模型
舌癌
颈淋巴结转移
Carcinogenesis
Tongue
Animal Model
Lymphnode
Metastasis