摘要
作为大肠癌的主要化疗药物之一，奥沙利铂的应用正逐步扩展到其他肿瘤的治疗中，然而奥沙利铂相关外周神经病变却限制了其临床应用。奥沙利铂神经毒性的机制尚未明确，最新研究认为急性神经毒性是通过改变Na＋短暂电导介导的；体外实验证实了丝裂原活化蛋白激酶（MAPK）在奥沙利铂慢性神经病变中的作用。多种指标可用于预测奥沙利铂相关的外周神经病变，为实现个体化药物治疗、提高化疗的连续性带来了希望。
As the main drug in colorectal cancer chemotherapy, oxaliplatin is gradually infiltrated into other malignancies therapy. But oxaliplatin-induced peripheral neuropathy limits its clinical application. The mechanisms of oxaliplatin neurotoxicity are not yet clear. Recent researches show that the acute neurotoxicity of oxaliplatin is mediated through changes in Na＋ transient conductances. And the function of the mitogen-aetivated protein kinases in chronic neuropathy has already been demonstrated in vitro. Furthermore, numerous indicators can be used to predict oxaliplatin-induced peripheral neuropathy, which bring the hope for improving the continuity of chemotherapy and realizing personalized medicine therapy.
出处
《国际肿瘤学杂志》
CAS
2012年第5期366-369,共4页
Journal of International Oncology
