摘要
目的:探讨鼻、鼻窦内翻性乳头状瘤中人乳头状瘤病毒(HPV)和EB病毒的感染率及临床意义。方法:用聚合酶链反应(PCR)方法检测30例有随访记录的鼻、鼻窦内翻性乳头状瘤及恶变的石蜡包埋组织标本中的人乳头状瘤病毒和EB病毒基因。结果:30例中检出HPV20例(66.7％),EB病毒12例(40％),其中9例乳头状瘤恶变组织中检出HPV单独感染4例(全部为HPV_(16)型),EB病毒单独感染4例,两者混合感染1例,即9例乳头状瘤恶变组织中100％存在肿瘤病毒感染;10例鼻息肉中则未检出HPV和EB病毒。EB病毒感染与鼻、鼻窦内翻性乳头状瘤的复发具有相关性。结论:鼻、鼻窦内翻性乳头状瘤不仅与HPV感染有关,可能与EB病毒也有关;HPV_(16)与内翻性乳头状瘤癌变有关,EBV与复发有一定相关。
Objective: To investigate the infection of Epstain - Barr virus (EBV) and human papillomavirus (HPV) in sinonasal inverted papilloma and its clinical significance. Method: EBV and HPV DNA were detected in paraffin -embedded tissues of 30 cases of sinonasal inverted papillomas and papilloma with malignant transformation by polymeras chain reaction. All of thes patients had complete following -up data. Result: EBV and HPV were found respectively in 12(40%) and 20(66. 7%) of the 30 cases. Among 9 papilloma cases with malignant transformation, EBV was positive in 4 ones. HPV was also positive in 4 ones, the other one was mixed infection of these two viruses. That is to say. tumor virus infected all of these 9 cases. But 10 nasal polyes contained neither HPV nor EBV. It was found that EBV infection had a relationship with the recurrence of inverted papilloma. Conclusion: Infection of HPV as well as EBV has a relationship with sinonasal inverted papillomas, HPV16 is related to malignant transformation and EBV is related to recurrence of sinonasal inverted papillomas.
出处
《西南国防医药》
CAS
2000年第2期68-70,共3页
Medical Journal of National Defending Forces in Southwest China
关键词
鼻内翻性
乳头状瘤
EB病毒
HPV
nasal inverted papilloma Epstein-Barr virus human papillomavirus
