摘要
目的分析影响血液病患者首次血小板输注疗效的因素。方法观察87例血液病患者输注机采血小板的疗效，所有患者均输入血小板10U（血小板数≥2．5×10^11个），观察输注后血小板计数纠正增加指数（CCI），分析病种、脾大、发热、年龄、性别对血小板首次输注有效率的影响。结果血小板输注有效病例为66例（有效率75．9％），血小板输注有效率再生障碍性贫血（AA）为80．0％、特发性血小板减少性紫癜（ITP）为78．1％、急性白血病（AL）为65．2％、骨髓增生异常综合征（MDS）为82．3％，不同病种有效率差异无统计学意义（χ2=2．88，P〉0．05）。发热感染者（31例）有效率为58．1％，明显低于无发热感染者（56例）的85．7％（χ2=8．3308，P〈0．01）；脾不大者（59例）有效率为86．4％，明显高于脾大者（28例）的53．6％（χ2=11．2033，P〈0．01）；男性、女性有效率分别为76．0％、75．7％，差异无统计学意义（χ2=0．0012，P〉0．05）；〈60周岁者与≥60周岁者有效率分别为74．5％、77．8％，差异无统计学意义（χ2=0．1231，P〉0．05）。结论发热及脾大是影响血液病患者首次血小板输注疗效的因素。
Objective To study the efficiency of the first time platelet transfusion in patients with blood diseases. Methods Investigate the effect of platelet transfusion in 87 patients with blood diseases.All the patients were transfused 10U platelet （platelet≥2.5×10^11 ）.Observe CCI after platelet transfusion and analyse the influence factors to the efficiency of the first time platelet transfusion such as the kind of diseases, splenomegaly, fever, age and sex. Results After platelet transfusion,66 patients （75.9 %） were effective.The efficancy rates were 80.0 %,78.1%,65.2 %,82.3 % in AA,ITP,AL, MDS （X2--2.88,P〉0.05）.In 31 patients with a fever and infaction the efficancy rate was 58.1%,but it was 85.7% in 56 patients without a fever and infaction （χ2=8.3308,P〈0.01）. The effieancy rate in 59 patients with non-splenomegaly was 86.4 %.It was higher than that in 28 patients with splenomegaly which was 53.6%（X2=11.2033,P〈0.01）.The efficancy rate was 76.0% in male patients and it was 75.7 % in female patients （χ2= 0.0012 ,P〉0.05）.The efficancy rate was 74.5 % in young group （〈60 years old） and 77.8 % in old group （〈60 years old）（χ2=0.1231 ,PM）.05）. Conclusion Fever and splenomegaly are the influence factors to the efficiency of the first time platelet transfusion.
出处
《白血病．淋巴瘤》
CAS
2012年第4期228-229,共2页
Journal of Leukemia & Lymphoma
关键词
血液病
血小板输注
治疗效果
Blood disease
Platelet transfusion
Trdatment outcome
