摘要
麻醉开胸犬,左心室和股动脉插管用压力换能器测左心室内压和血压;电磁流量计测心输出量、冠状窦和颈内动脉血流量;多道生理记录仪记录各项指标.iv绞股蓝皂甙5或10 mg/kg和人参皂甙10mg/kg能明显降低犬血压和总外周阻力、脑血管与冠状血管阻力,增加冠脉流量,减慢心率,使心脏张力-时间指数下降,对心肌收缩性能和心脏泵血功能无明显影响.与等剂量人参皂甙比较,绞股蓝皂甙的作用略强.
The effects of gypenosides(Gyp)from Gynostema pentaphyllum(Thunb)Mak on the heart function and hemodynamics were studied in 8 anesthetized open chest dogs,in comparison with the action of ginsenosides(Gin)from Panax ginseng C.A.Mey.The arterial and left ventricular pressures were measured with a MPU-0.5 or CYS-0.5 pressure transducer and the cardiac output and the internal carotid arterial and coronary blood flows were measured with a MF-27 or MFV-1200 electromagnetic blood flowmctcr.The signal tracings were recorded on RM-86 polygraph.It was observed that Gyp 5 or 10 mg/kg iv,and Gin 10 mg/kg iv,significantly lowered systolic pressure,diastolic pressure and mean arterial pressure,andmarkedly decreased total peripheral vessel resistance,brain vessel resistance and coronary resistance.It was found that the coronary flow was raised and the heart rate was lowered by Gyp and Gin.The lowering of myocardiac oxygen consumption after the administration of Gyp and Gin could be explained by the decreasing of cardiac tension-time index and the slowing of heart rate.Nevertheless,it was insignificant that Gyp and Gin affected the myocardiac contractility and heart pump function.The effects of Gyp are slightly more potent than Gin.
出处
《中国药理学与毒理学杂志》
CAS
CSCD
北大核心
1990年第1期17-20,共4页
Chinese Journal of Pharmacology and Toxicology
关键词
绞股蓝
皂甙
人参
血流动力学
gypenosides
ginscnosidcs
heart function tests
hemodynamics
