摘要
建立了气相色谱仪测定组织中苦豆碱含量的方法,并研究其在动物体内的时间过程。兔ⅳ苦豆碱的血浓-时间曲线符合二房室模型。分布半衰期t_(1/2)为5.5 min,消除半衰期为2 h,组织分布广,心、肝、肺、脂肪中含量均较血浆中高;剂量25 mg/kg时的分布容积V_((?))高达2.21L/kg;大鼠36 h内尿排泄药量为13.4%±5.0%,胆道几乎不排泄。牛血清白蛋白结合率为76.8%±5.1%。小鼠灌胃后以一级过程吸收,半量吸收时间为80.8 min。
A method of gas chromatography for determination of Aloperinc in biological specimens was developed and used in the study of its pharmacokinetics in animals. The pharmacokinetics of aloperine in rabbits were fitted by an open two compartment model, t_(1/2β)=120 min. High levels of aloperine were found in heart, liver, lung and adipose tissure. About 13.4% of the dose was recovered from the rat urine within 36 hours. The protein binding ratio is 76.8±5.1%. After oral administration, aloperine was readily absorbed from mouse gastrointerstinal tract wity half absorption time of 80.0 min.
出处
《中国药科大学学报》
CAS
CSCD
北大核心
1990年第6期361-363,共3页
Journal of China Pharmaceutical University
关键词
苦豆碱
气相色谱法
药代动力学
Alopcrine
Gas chromatography
Pharmacokinetics
