摘要
小檗碱(berberine, BER)和四氢小檗碱(tetrahydroberberine, THB)同属原小檗碱型(protoberbcrine)生物碱。近来发现这类生物碱心血管作用明显,已报道有降压、抗心律失常、扩血管和钙拮抗等,其中小檗碱已用于临床。为进一步阐明其作用方式。
The effects of berberine (BER) and tetrahydroberberine (THB) on α_1, α_2-adrenoceptors were investigated. BER was shown to have moderate affinities to α_1, α_2-adrenoceptots, and the values of K_i were 0.42 and 1.94 μmol/L, respectively. Its blocking actions on presynapti(?) α_2-and postsynaptic α_1-receptor were found in rat anococeygeus muscle and vas deferens, with pA_2 values of 5.34 and 6.23, respectively. THB seemed to have selectivity for α_1-receptors (K_i=1.72 μmol/L) and no effects on α_2-receptors (K_i>100 μmol/L).
出处
《中国药科大学学报》
CAS
CSCD
北大核心
1990年第5期309-311,共3页
Journal of China Pharmaceutical University
关键词
小檗碱
四氢小檗碱
Α-受体
Berberine
Tetrahydroberberine
α-Adrenoceptors
Anococcygeus muscel
Vas deferens
