摘要
目的:对苏木的种子进行化学成分研究。方法:采用各种柱层析方法, 从苏木种子分离得到化合物, 并通过波谱方法确定其化学结构。此外, 运用 MTT 分析法测定了这些化合物对 SF-268,MCF-7 和 HepG2 细胞株的细胞毒活性。结果:从苏木种子中分离鉴定了 4 个卡山烷型二萜, 分别为 phanginin L (1), phanginin M (2), phanginin I (3), phanginin G (4)。结论:Phanginin L (1) and phanginin M (2)为新化合物。化合物 1 对 HepG2 细胞株有中等抑制活性, 其 IC50 为 9.13 μg·mL-1。
AIM：To study the chemical components of the seeds of Caesalpinia sappan.METHODS：Compounds were isolatedand purified by column chromatography.Their structures were elucidated on the basis of spectroscopic methods.In addition,the cytotoxicactivity of these compounds were evaluated using SF-268,MCF-7 and HepG2 cell lines by the MTT assay.RESULTS：Fourcassane diterpenoids were obtained and their structures were identified as phanginin L（1）,phanginin M（2）,phanginin I（3）,phangininG（4）.CONCLUSION：Phanginin L（1） and phanginin M（2） are new cassane diterpenoids.Compound 1 showed moderate cytotoxicityagainst HepG2 cell line with IC50 of 9.13 μg·mL-1.
出处
《中国天然药物》
SCIE
CAS
CSCD
2012年第3期218-221,共4页
基金
supported by the Postgraduate Innovation Project of Jiangsu Province,China (No.CXZZ11_0802)~~
